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Identification and confirmation of 14-3-3 zeta as a novel target of ginsenosides in brain tissues

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (4)

Background: Ginseng can help regulate brain excitability, promote learning and memory, and resist cerebral ischemia in the central nervous system. Gin......

Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (4)

Background: Mitochondrial dysfunction is one of the significant reasons for Alzheimer's disease (AD). Ginsenosides, natural molecules extracted from P......

Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (3)

Mitochondrial dysfunction contributes to the pathogenesis and prognosis of many common disorders, including neurodegeneration, stroke, myocardial infa......

The increasing hematopoietic effect of the combined treatment of Korean Red Ginseng and Colla corii asini on cyclophosphamide-induced immunosuppression in mice

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (5)

Background: Hematopoiesis is the production of blood cells from hematopoietic stem cells (HSCs) that reside in the bone marrow. Cyclophosphamide (CTX)......

Enhancement of skin barrier and hydration-related molecules by protopanaxatriol in human keratinocytes

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Protopanaxatriol (PPT) is a secondary intestinal metabolite of ginsenoside in ginseng. Although the effects of PPT have been reported in v......

Prebiotics enhance the biotransformation and bioavailability of ginsenosides in rats by modulating gut microbiota

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Gut microbiota mainly function in the biotransformation of primary ginsenosides into bioactive metabolites. Herein, we investigated the ef......

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. Enhancing hippocampal neurogenesis by promoting prolife......

Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Panax stipuleanatus represents a folk medicine for treatment of inflammation. However, lack of experimental data does not confirm its func......

20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-alpha/caspase8 signaling cascades

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Acute promyelocytic leukemia (APL) is a hematopoietic malignancy driven by promyelocytic leukemia-retinoic acid receptor A (PML-RARA) fusi......

Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers f......

Characterization of ginsenoside compound K loaded ionically cross-linked carboxymethyl chitosan-calcium nanoparticles and its cytotoxic potential against prostate cancer cells

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Backgroud: Ginsenoside compound K (GK) is a major metabolite of protopanaxadiol-type ginsenosides and has remarkable anticancer activities in vitro an......

Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

Background: Panax ginseng is one of the most important medicinal plants and is usually harvested after 5 to 6 years of cultivation in Korea. Heavy met......

Ginseng polysaccharides: A potential neuroprotective agent

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (2)

The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the......

Stem-leaves of Panax as a rich and sustainable source of less-polar ginsenosides: comparison of ginsenosides from Panax ginseng, American ginseng and Panax notoginseng prepared by heating and acid treatment

期刊: JOURNAL OF GINSENG RESEARCH, 2021; 45 (1)

Background: Ginsenosides, which have strong biological activities, can be divided into polar or less-polar ginsenosides. Methods: This study evaluated......

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