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Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Background Congenital human cytomegalovirus (CMV) infection remains largely unrecognized and underemphasized in medical practice. This study aimed to ......

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Seasonal influenza A virus (IAV) infections are among the most important global health problems. FDA-approved antiviral therapies against IAV include ......

Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

In mid-November 2020, deaths of whooper swan were reported in the Yellow River Reservoir Area, China. In the present study, we describe the genetic ch......

Restoration of a functional antiviral immune response to chronic HBV infection by reducing viral antigen load: if not sufficient, is it necessary?

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

The prolonged viral antigen stimulation is the driving force for the development of immune tolerance to chronic hepatitis B virus (HBV) infection. The......

Assessing the effects of a two-amino acid flexibility in the Hemagglutinin 220-loop receptor-binding domain on the fitness of Influenza A(H9N2) viruses

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

The enzootic and zoonotic nature of H9N2 avian influenza viruses poses a persistent threat to the global poultry industry and public health. In partic......

Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

MW33 is a fully humanized IgG1 kappa monoclonal neutralizing antibody, and may be used for the prevention and treatment of coronavirus disease 2019 (C......

Maternal hepatitis B e antigen can be an indicator for antiviral prophylaxis of perinatal transmission of hepatitis B virus

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

As a high-risk factor of perinatal HBV transmission, the potential role of maternal hepatitis B e antigen (HBeAg) to guide antiviral prophylaxis has n......

Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Seasonal human coronaviruses (HCoVs) including HCoV-229E, -OC43, -NL63, and -HKU1 widely spread in global human populations. However, the relevance of......

PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Influenza H3N8 viruses have been recovered frequently from wild bird species, including Anseriformes (primarily from migratory ducks) and Charadriifor......

The genetic feature and virulence determinant of highly virulent community-associated MRSA ST338-SCCmec Vb in China

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

ST59 is the predominant pathotype of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in China. As a variant of ST59, there ......

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that poses significant threats to global public health. Macrophages and dendritic cells are......

Genomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Clostridioides difficile sequence type (ST) 37 (ribotype 017) is one of the most prevalent genotypes circulating in China. However, its genomic evolut......

A new nairo-like virus associated with human febrile illness in China

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

Several nairo-like viruses have been discovered in ticks in recent years, but their relevance to public health remains unknown. Here, we found a patie......

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

To curb the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), multiple platf......

Acquiring high expression of suilysin enable non-epidemic Streptococccus suis to cause streptococcal toxic shock-like syndrome (STSLS) through NLRP3 inflammasome hyperactivation

期刊: EMERGING MICROBES & INFECTIONS, 2021; 10 (1)

The epidemic Streptococcus suis (S. suis) strain [Sequence type (ST) 7] was gradually evolving from the non-epidemic ST1 strain and got the ability fo......

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