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Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Polystyrene nanoparticles (PS-NPs) as an issue of global environmental concern, have been shown to induce hepatic toxicity via triggering oxidative in......

JIF:3.779

Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/beta-catenin pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (6)

Up-regulation of family with sequence similarity 83 member D (FAM83D) has been acknowledged as a vital contributor for the carcinogenesis of numerous ......

JIF:3.779

Restraint of FAM60A has a cancer-inhibiting role in pancreatic carcinoma via the effects on the Akt/GSK-3 beta/beta-catenin signaling pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (6)

Family with sequence similarity 60A (FAM60A) has been reported as a new cancer-related protein that affects the malignant progression of some cancers.......

JIF:3.779

Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (10)

Phthalates may interfere with the biosynthesis of steroid hormones in the adrenal cortex. Bis (2-butoxyethyl) phthalate (BBOP) is a phthalate containi......

JIF:3.779

RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (3)

The critical roles of E3 ubiquitin ligase RNF168 have been widely revealed in various tumors, however, its roles in lung cancer progression are still ......

JIF:3.779

Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (4)

Uranium (U) induces generation of excessive intracellular reactive oxygen species (ROS), which is generally considered as a possible mediator of U-tri......

JIF:3.779

Estrogen receptor-alpha 36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Hepatocellular carcinoma (HCC) is a highly malignant disease that currently lacks effective treatment. Epidemiological studies have suggested the prev......

JIF:3.779

MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (4)

The clinical application of doxorubicin (Dox) is limited due to its cardiotoxicity, while the pathogenesis remains to be fully understood. Recent stud......

JIF:3.779

Effects of mammalian target of rapamycin and aryl hydrocarbon receptor-mediating autophagy signaling on the balance of Th17/Treg cells during perinatal bisphenol A exposure in female offspring mice

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (7)

Bisphenol A (BPA)'s immunotoxic properties have received increasing interest, which can lead to immune dysfunction and related disease development. Ho......

JIF:3.779

1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (10)

1,3-Dichloro-2-propanol (1,3-DCP) is a representative chloropropane environmental contaminant with multiple toxicities. Ferroptosis is a novel iron-de......

JIF:3.779

Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Circular RNA-synaptosome associated protein 47 (circ-SNAP47; Hsa_circ_0016760) is oncogenic in non-small-cell lung cancer (NSCLC); however, its role i......

JIF:3.779

EHD1 promotes the cancer stem cell (CSC)-like traits of glioma cells via interacting with CD44 and suppressing CD44 degradation

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (9)

Plenty of evidence has shown that endocytosis plays a key role in cancer progression; however, its effects in the progression of cancer stem cells (CS......

JIF:3.779

NF-kappa B mediates silica-induced pulmonary inflammation by promoting the release of IL-1 beta in macrophages

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (9)

Long-term exposure to respirable silica particles causes pulmonary inflammation and fibrosis primarily promoted by cytokines released from alveolar ma......

JIF:3.779

Leucine-rich repeat kinase 2 is protective during acute kidney injury through its activation of autophagy in podocytes

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (12)

Leucine-rich repeat kinase 2 (LRRK2) is a known regulator of autophagy in a range of cell types. Here, we investigated the role of LRRK2-associated au......

JIF:3.779

Natural swietenine attenuates diabetic nephropathy by regulating the NF-kappa B/NLRP3/Caspase-1 signaling pathways: In vivo and in vitro study

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (12)

Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates inflammation and oxidative stress, and diabetic nephropathy has a close connect......

JIF:3.779

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