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Mining cell-cell signaling in single-cell transcriptomics atlases

期刊: CURRENT OPINION IN CELL BIOLOGY, 2022; 76 ()

Recent advances in single-cell RNA sequencing (scRNA-seq) techniques lead to an explosion of single-cell atlases from diverse biological contexts. The......

JIF:7.455

Endoplasmic reticulum composition and form: Proteins in and out

期刊: CURRENT OPINION IN CELL BIOLOGY, 2021; 71 ()

The endoplasmic reticulum (ER) is the main harbor for newly synthesized proteins in eukaryotic cells. Through a continuous membrane network of sheets ......

Polarity during tissue repair, a multiscale problem

期刊: CURRENT OPINION IN CELL BIOLOGY, 2020; 62 ()

Tissue repair is essential for all organisms, as it protects the integrity and function of tissues and prevents infections and diseases. It takes plac......

Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology

期刊: CURRENT OPINION IN CELL BIOLOGY, 2020; 63 ()

Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this ......

Progress in deciphering trophoblast cell differentiation during human placentation

期刊: CURRENT OPINION IN CELL BIOLOGY, 2020; 67 ()

The maintenance of gestational well-being requires the proper development of both the embryo and the placenta. Placental trophoblast cells are the maj......

Protein phase separation in mitosis

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 60 ()

Through phase separation, some proteins form liquid-like condensates or droplets which can flow, fuse, and even deform when pressure is applied. In so......

JIF:8.23

The extended chondrocyte lineage: implications for skeletal homeostasis and disorders

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

Endochondral bone formation relies on a finely controlled sequence of chondrocyte proliferation, maturation and hypertrophy that establishes the growt......

JIF:8.23

Core autophagy genes and human diseases

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

Autophagy involves the formation of double-membrane autophagosomes and their delivery to lysosomes for degradation. In response to various endogenous ......

JIF:8.23

Dual genetic approaches for deciphering cell fate plasticity in vivo: more than double

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

Unravelling stem cell fate plasticity is significant for understanding pathophysiology and exploring new therapeutic targets. The Cre-loxP genetic sys......

JIF:8.23

Role of the transcriptional coactivators YAP/TAZ in liver cancer

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers worldwide. Although the etiologies for liver oncogenesis a......

JIF:8.23

TGF-beta signaling in cell fate control and cancer

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

Members of the transforming growth factor-beta (TGF-beta) family regulate cell fate decisions during early embryonic development and tissue homeostasi......

JIF:8.23

The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling

期刊: CURRENT OPINION IN CELL BIOLOGY, 2019; 61 ()

The Hedgehog (HH) pathway plays a pivotal role in regulating a diverse array of events from embryonic tissue patterning to adult organ self-renewal. A......

JIF:8.23

To eat or not to eat - the metabolic flavor of ferroptosis

期刊: CURRENT OPINION IN CELL BIOLOGY, 2018; 51 ()

Ferroptosis is a newly defined iron-dependent, non-apoptotic mode of cell death with necrotic morphology. Distinctive from other death mechanisms, fer......

JIF:8.23

Formation and maturation of autophagosomes in higher eukaryotes: a social network

期刊: CURRENT OPINION IN CELL BIOLOGY, 2018; 53 ()

Autophagy, a self-eating process conserved from yeast to mammals, is critical for maintaining cell homeostasis. It involves the formation of a double-......

JIF:8.23

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