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YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1

期刊: HAEMATOLOGICA, 2022; 107 (10)

Hematopoietic stem cells (HSC) give rise to the cells of the blood system over the whole lifespan. N6-methyladenosine (m6A), the most prevalent RNA mo......

JIF:4.7

A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia

期刊: HAEMATOLOGICA, 2022; 107 (10)

Chemotherapy is the primary treatment option for acute myeloid leukemia (AML), but leukemic stem cells (LSC) can sur-vive chemotherapy for disease rec......

JIF:4.7

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway

期刊: HAEMATOLOGICA, 2022; 107 (1)

Hematopoietic stem cells (HSC) are dominantly quiescent under homeostasis, which is a key mechanism of maintaining the HSC pool for life-long hematopo......

JIF:4.7

The glycolytic enzyme PFKFB3 determines bone marrow endothelial progenitor cell damage after chemotherapy and irradiation

期刊: HAEMATOLOGICA, 2022; 107 (10)

Bone marrow (BM) endothelial progenitor cell (EPC) damage of unknown mechanism delays the repair of endothelial cells (EC) and recovery of hematopoies......

JIF:4.7

Critical role of peroxisome proliferator-activated receptor a in promoting platelet hyperreactivity and thrombosis under hyperlipidemia

期刊: HAEMATOLOGICA, 2022; 107 (6)

Platelet hyperreactivity and increased atherothrombotic risk are specifically associated with dyslipidemia. Peroxisome proliferator-activated receptor......

JIF:4.7

Correction of RNA splicing defect in beta(654)-thalassemia mice using CRISPR/Cas9 gene-editing technology

期刊: HAEMATOLOGICA, 2022; 107 (6)

beta(654)-thalassemia is a prominent Chinese subtype of beta-thalassemia, representing 17% of all cases of beta-thalassemia in China. The molecular me......

JIF:4.7

Fenofibrate reduces osteonecrosis without affecting antileukemic efficacy in dexamethasone-treated mice

期刊: HAEMATOLOGICA, 2021; 106 (8)

Recent clinical trials in children with acute lymphoblastic leukemia (ALL) indicate that severe hypertriglyceridemia (>1000 mg/dL) during therapy i......

MYC rearrangement but not extra MYC copies is an independent prognostic factor in patients with mantle cell lymphoma

期刊: HAEMATOLOGICA, 2021; 106 (5)

Mantle cell lymphoma (MCL) with MYC rearrangement (MYC-R) is rare and little is known about the importance of MYC extra copies (EC) in the absence of ......

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