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From primordial germ cells to spermatids in Caenorhabditis elegans

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 127 ()

Development of a syncytial germline for gamete formation requires complex regulation of cytokinesis and cytoplasmic remodeling. Recently, several unco......

JIF:6.273

mTORC1/rpS6 and p-FAK-Y407 signaling regulate spermatogenesis: Insights from studies of the adjudin pharmaceutical/toxicant model*

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

In rodents and humans, the major cellular events at spermatogenesis include self-renewal of spermatogonial stem cells and undifferentiated spermatogon......

JIF:6.273

Technical challenges in defining RNA modifications

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 127 ()

It is well established that DNA base modifications play a key role in gene regulation during development and in response to environmental stress. This......

JIF:6.273

A laminin-based local regulatory network in the testis that supports spermatogenesis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

In adult rat testes, the basement membrane is structurally constituted by laminin and collagen chains that lay adjacent to the blood-testis barrier (B......

JIF:6.273

Non-viral approaches for somatic cell reprogramming into cardiomyocytes

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 122 ()

Heart disease is the leading cause of human deaths worldwide. Due to lacking cardiomyocytes with replicative capacity and cardiac progenitor cells wit......

JIF:6.273

Assembly and recognition of keratins: A structural perspective

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 128 ()

Keratins are one of the major components of cytoskeletal network and assemble into fibrous structures named intermediate filaments (IFs), which are im......

JIF:6.273

The roles of transcription, chromatin organisation and chromosomal processes in holocentromere establishment and maintenance

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 127 ()

The centromere is a unique functional region on each eukaryotic chromosome where the kinetochore assembles and orchestrates microtubule attachment and......

JIF:6.273

Keratin 17 in psoriasis: Current understanding and future perspectives

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 128 ()

Keratin 17 (K17) is a multifaceted cytoskeletal protein that is not commonly expressed in the epidermis under normal physiological conditions. However......

JIF:6.273

Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 128 ()

The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular components in tissues. In addition to functioning as a struc......

JIF:6.273

Planar cell polarity (PCP) proteins support spermatogenesis through cytoskeletal organization in the testis

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

Few reports are found in the literature regarding the role of planar cell polarity (PCP) in supporting sper-matogenesis in the testis. Yet morphologic......

JIF:6.273

The mechanisms and functions of microRNAs in mediating the fate determinations of human spermatogonial stem cells and Sertoli cells

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

Human spermatogonial stem cells (SSCs) and Sertoli cells might have the applications in reproduction and regenerative medicine. Abnormal spermatogenes......

JIF:6.273

Role of laminin and collagen chains in human spermatogenesis-Insights from studies in rodents and scRNA-Seq transcriptome profiling

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2022; 121 ()

Studies have demonstrated that biologically active fragments are generated from the basement membrane and the Sertoli cell-spermatid adhesion site kno......

JIF:6.273

Manganese homeostasis at the host-pathogen interface and in the host immune system

期刊: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2021; 115 ()

Manganese serves as an indispensable catalytic center and the structural core of various enzymes that participate in a plethora of biological processe......

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