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Clinical characteristics and survival outcomes of newly diagnosed multiple myeloma patients presenting with extramedullary disease: A retrospective study

期刊: LEUKEMIA RESEARCH, 2022; 115 ()

The aim of study was to assess the clinical characteristics, survival outcomes of newly diagnosed multiple myeloma (NDMM) patients with extramedullary......

JIF:2.077

PTPN11 mutations in adult acute myeloid leukaemia: Prevalence and clinical implications in the context of NPM1 mutation

期刊: LEUKEMIA RESEARCH, 2022; 118 ()

More than 90% of NPM1-mutated acute myeloid leukaemia (NPM1mut AML) patients have been determined to harbour other known concurrent mutations. However......

JIF:2.077

Effects of conventional interventions on early-stage primary cutaneous marginal zone lymphoma: A population-based study

期刊: LEUKEMIA RESEARCH, 2022; 114 ()

Background: Information on the outcomes and treatments of early-stage (I/II) primary cutaneous marginal zone lymphoma (PCMZL) is limited. This study a......

JIF:2.077

Bortezomib-resistant multiple myeloma patient-derived xenograft is sensitive to anti-CD47 therapy

期刊: LEUKEMIA RESEARCH, 2022; 122 ()

Multiple myeloma (MM) remains an incurable hematologic malignancy due to its frequent drug resistance and relapse. Cluster of Differentiation 47 (CD47......

JIF:2.077

Multiple cells of origin in common with various types of mouse N-Myc acute leukemia

期刊: LEUKEMIA RESEARCH, 2022; 117 ()

Little is known regarding whether the cell of origin differs among different leukemia types. To address this fundamental issue, we determined the cell......

JIF:2.077

MiR-665 suppresses the progression of diffuse large B cell lymphoma (DLBCL) through targeting LIM and SH3 protein 1 (LASP1)

期刊: LEUKEMIA RESEARCH, 2022; 112 ()

Diffuse large B cell lymphoma (DLBCL), the most common type of non-Hodgkin lymphoma worldwide, is aggressive and highly heterogeneous. MiR-665 was fou......

JIF:2.077

Prevalence, clinical characteristics and treatment outcome of factor X deficiency in a consecutive cohort of primary light-chain amyloidosis

期刊: LEUKEMIA RESEARCH, 2022; 120 ()

Factor X (FX) deficiency is prevalent in light-chain (AL) amyloidosis but its clinical significance was not investigated deeply. We conducted a retros......

JIF:2.077

DDGP followed by radiotherapy vs VIPD followed by radiotherapy in newly diagnosed early NK/T-cell lymphoma

期刊: LEUKEMIA RESEARCH, 2022; 118 ()

Purpose: To explore the best treatment for early natural killer/T (NK/T)-cell lymphoma, we compared the efficacy and safety of DDGP (pegaspargase, gem......

JIF:2.077

Development of a new risk scoring system based on spleen involvement and the lymphocyte/monocyte ratio for follicular lymphoma patients

期刊: LEUKEMIA RESEARCH, 2022; 123 ()

Background: This study aimed to retrospectively evaluate a large Chinese cohort's baseline characters and develop a new predictive scoring system. Met......

JIF:2.077

LncRNA MEG3 promotes the sensitivity of bortezomib by inhibiting autophagy in multiple myeloma

期刊: LEUKEMIA RESEARCH, 2022; 123 ()

Background: Bortezomib resistance hampers the long-term survival of multiple myeloma (MM) patients. Our previous study has proved that downregulated l......

JIF:2.077

MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression

期刊: LEUKEMIA RESEARCH, 2022; 120 ()

Background: Deregulated expression of miRNAs contributes to the development of numerous malignancies, including acute myeloid leukemia (AML). The pres......

JIF:2.077

Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis

期刊: LEUKEMIA RESEARCH, 2022; 113 ()

Background: Circular RNAs (circRNAs) have been reported to play critical roles in the malignant progression of diverse human cancers, including multip......

JIF:2.077

MiR-197-3p reduces bortezomib resistance in multiple myeloma by inhibiting IL-6 expression in a MEAF6-dependent manner

期刊: LEUKEMIA RESEARCH, 2022; 114 ()

Objective: This study investigated the mechanism by which miR-197-3p regulated IL-6 expression and reduced bortezomib (BTZ) resistance in multiple mye......

JIF:2.077

CD5-positive marginal zone lymphoma: Clinicopathological features and survival outcomes

期刊: LEUKEMIA RESEARCH, 2022; 117 ()

Background: CD5 expression in different B-cell lymphomas has different clinicopathological and prognosis and the value of CD5 expression in marginal z......

JIF:2.077

Targeting cyclin-dependent kinases 4/6 inhibits survival of megakaryoblasts in acute megakaryoblastic leukaemia

期刊: LEUKEMIA RESEARCH, 2022; 120 ()

Acute megakaryoblastic leukaemia (AMKL) is characterized by expansion of megakaryoblasts, which are hyper -proliferative cells that fail to undergo di......

JIF:2.077

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