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Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Transketolase (Tkt), an enzyme in pentose phosphate pathway, has been reported to regulate genome instability and cell survival in cancers. Yet, the r......

JIF:15.478

Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Astrocytes play a key role in the response to injury and noxious stimuli, but its role in myocardial ischemia-reperfusion (I/R) injury remains largely......

JIF:15.478

Sympathetic nerve innervation and metabolism in ischemic myocardium in response to remote ischemic perconditioning

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Sympathetic nerve denervation after myocardial infarction (MI) predicts risk of sudden cardiac death. Therefore, therapeutic approaches limit infarct ......

JIF:15.478

Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Treatment options for myocarditis are currently limited. Inhibition of calpains has been shown to prevent Coxsackievirus B3 (CVB3)-induced cardiac inj......

JIF:15.478

Bone marrow-derived naive B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

The role of adaptive immunity in myocardial recovery post myocardial infarction (MI), particularly the immune response by B lymphocytes, remains elusi......

JIF:15.478

NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Impaired endothelium-dependent vasodilation has been suggested to be a key component of coronary microvascular dysfunction (CMD). A better understandi......

JIF:15.478

Loss of NPPA-AS1 promotes heart regeneration by stabilizing SFPQ-NONO heteromer-induced DNA repair

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

The role of long non-coding RNA (lncRNA) in endogenous cardiac regeneration remains largely elusive. The mammalian cardiomyocyte is capable of regener......

JIF:15.478

Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

Accumulating evidence suggests that autophagy dysfunction plays a critical role in myocardial ischemia/reperfusion (I/R) injury. However, the underlin......

JIF:15.478

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

期刊: BASIC RESEARCH IN CARDIOLOGY, 2022; 117 (1)

The stellate ganglia play an important role in cardiac remodeling after myocardial infarction (MI). This study aimed to investigate whether adiponecti......

JIF:15.478

HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype

期刊: BASIC RESEARCH IN CARDIOLOGY, 2021; 116 (1)

Appropriately manipulating macrophage M1/M2 phenotypic transition is a promising therapeutic strategy for tissue repair after myocardial infarction (M......

Pathogenesis of arrhythmogenic cardiomyopathy: role of inflammation

期刊: BASIC RESEARCH IN CARDIOLOGY, 2021; 116 (1)

Arrhythmogenic cardiomyopathy (AC) is an inherited disease characterized by progressive breakdown of heart muscle, myocardial tissue death, and fibrof......

Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases

期刊: BASIC RESEARCH IN CARDIOLOGY, 2021; 116 (1)

Metabolic function and energy production in eukaryotic cells are regulated by mitochondria, which have been recognized as the intracellular 'powerhous......

LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway

期刊: BASIC RESEARCH IN CARDIOLOGY, 2021; 116 (1)

Metabolic modulation is a promising therapeutic approach to prevent adverse remodeling of the ischemic heart. Because little is known about the involv......

Exercise-induced peptide TAG-23 protects cardiomyocytes from reperfusion injury through regulating PKG-cCbl interaction

期刊: BASIC RESEARCH IN CARDIOLOGY, 2021; 116 (1)

Recent studies have revealed that proper exercise can reduce the risk of chronic disease and is beneficial to the body. Peptides have been shown to pl......

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