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Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Neuroinflammation and oxidative stress plays an important role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhag......

HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Two activation states of reactive astrocytes termed A1 and A2 subtypes emerge at the lesion sites following spinal cord injury (SCI). A1 as......

MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of alpha 5GABA(A) receptors in aged mice

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background: Perioperative neurocognitive disorder (PND) is a long-term postoperative complication in elderly surgical patients. The underlying mechani......

Dexamethasone enhances the efficacy of atorvastatin in inhibiting excessively inflammation-induced abnormal angiogenesis by regulating macrophages

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background We have recently showed that atorvastatin (ATO) combined with low dose of dexamethasone (DEX) was more efficacious in treating patients wit......

EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Central post-stroke pain (CPSP) is a chronic and intolerable neuropathic pain syndrome following a cerebral vascular insult, which negative......

Sex difference in the interrelationship between TNF-alpha and oxidative stress status in first-episode drug-naive schizophrenia

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background: Increasing evidence indicates that dysregulated TNF-alpha and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. A......

NAD(+) improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1 alpha pathway

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background: Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a prom......

Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Our previous study indicated that hypoxic preconditioning reduced receptor interacting protein (RIP) 3-mediated necroptotic neuronal death ......

Thymosin beta 4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappa B signaling axis in APP/PS1 mice

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background: Thymosin beta 4 (T beta 4) is the most abundant member of the beta-thymosins and plays an important role in the control of actin polymeriz......

The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the health care system. Conventional medications are usual......

Early glycolytic reprogramming controls microglial inflammatory activation

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background: Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory ac......

Chronic colitis exacerbates NLRP3-dependent neuroinflammation and cognitive impairment in middle-aged brain

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Neuroinflammation is a major driver of age-related brain degeneration and concomitant functional impairment. In patients with Alzheimer's d......

Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Germinal matrix hemorrhage (GMH) is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage en......

Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia-reperfusion

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Celastrol (cel) was one of the earliest isolated and identified chemical constituents of Tripterygium wilfordii Hook. f. Based on a cel pro......

Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation

期刊: JOURNAL OF NEUROINFLAMMATION, 2021; 18 (1)

Background Microglia are resident innate immune cells in the brain, and activation of these myeloid cells results in secretion of a variety of pro-inf......

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