期刊： GENES & DEVELOPMENT, 2022; 36 (5-6)
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that is a vital regulator of adipogenesis, insulin sensitivity, an......
期刊： GENES & DEVELOPMENT, 2022; 36 (15-16)
Bmi1 is essential for normal and leukemic hematopoiesis, but its target genes in hematopoietic stem cells (HSCs) are incompletely understood. In this ......
期刊： GENES & DEVELOPMENT, 2022; 36 (7-8)
In this study, Yue et al. present the structure of the Hat1-Hat2 acetyltransferase complex bound to Asf1-H3-H4, which shows that the core domains of H......
期刊： GENES & DEVELOPMENT, 2022; 36 (3-4)
In this study, Zheng et al. investigated how BEN factors, a recently recognized DNA binding module, identify their targets in humans. They characteriz......
期刊： GENES & DEVELOPMENT, 2021; 35 (15-16)
Knowledge of how Mediator and TFIID cross-talk contributes to promoter-enhancer (P-E) communication is important for elucidating the mechanism of enha......
期刊： GENES & DEVELOPMENT, 2021; 35 (15-16)
Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high propensity to metastasize. Despite the importance of metasta......
期刊： GENES & DEVELOPMENT, 2021; 35 (9-10)
The conserved meiosis-specific kinetochore regulator, meikin (Moa1 in fission yeast) plays a central role in establishing meiosis-specific kinetochore......
期刊： GENES & DEVELOPMENT, 2021; 35 (15-16)
The meninges are important for brain development and pathology. Using single-cell RNA sequencing, we have generated the first comprehensive transcript......
期刊： GENES & DEVELOPMENT, 2021; 35 (3-4)
SUMO modification regulates diverse cellular processes by targeting hundreds of proteins. However, the limited number of sumoylation enzymes raises th......
期刊： GENES & DEVELOPMENT, 2021; 35 (1-2)
p53 is an intensely studied tumor-suppressive transcription factor. Recent studies suggest that the RNA-binding protein (RBP) ZMAT3 is important in me......
期刊： GENES & DEVELOPMENT, 2020; 34 (3-4)
Oocytes are indispensable for mammalian life. Thus, it is important to understand how mature oocytes are generated. As a critical stage of oocytes dev......
期刊： GENES & DEVELOPMENT, 2020; 34 (7-8)
The Hippo pathway is a master regulator of tissue homeostasis and organ size. NF2 is a well-established tumor suppressor, and loss of NF2 severely com......
期刊： GENES & DEVELOPMENT, 2020; 34 (9-10)
Autophagy captures intracellular components and delivers them to lysosomes for degradation and recycling. Conditional autophagy deficiency in adult mi......
期刊： GENES & DEVELOPMENT, 2020; 34 (9-10)
Telomeres consist of TTAGGG repeats bound by protein complexes that serve to protect the natural end of linear chromosomes. Most cells maintain telome......
期刊： GENES & DEVELOPMENT, 2020; 34 (13-14)
Hematopoietic stem cell (HSC) ontogeny is accompanied by dynamic changes in gene regulatory networks. We performed RNA-seq and histone mark ChIP-seq t......
