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Characterization of the SARS-CoV-2 E Protein: Sequence, Structure, Viroporin, and Inhibitors

期刊: PROTEIN SCIENCE, 2021; 30 (6)

The COVID-19 epidemic is one of the most influential epidemics in history. Understanding the impact of coronaviruses (CoVs) on host cells is very impo......

Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in beta-carboxysome

期刊: PROTEIN SCIENCE, 2021; 30 (8)

Carboxysome is an icosahedral self-assembled microcompartment that sequesters RuBisCO and carbonic anhydrases within a selectively permeable protein s......

Macromolecular regulators have matching effects on the phase equilibrium and interfacial tension of biomolecular condensates

期刊: PROTEIN SCIENCE, 2021; 30 (7)

The interfacial tension of phase-separated biomolecular condensates affects their fusion and multiphase organization, and yet how this important prope......

Liquid-liquid phase separation of Tau by self and complex coacervation

期刊: PROTEIN SCIENCE, 2021; 30 (7)

The liquid-liquid phase separation (LLPS) of Tau has been postulated to play a role in modulating the aggregation property of Tau, a process known to ......

Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer

期刊: PROTEIN SCIENCE, 2021; 30 (6)

Dicer is a member of the ribonuclease III enzyme family and processes double-stranded RNA into small functional RNAs. The variation in the domain arch......

The reduced form of the antibody CH2 domain

期刊: PROTEIN SCIENCE, 2021; 30 (9)

Among the immunoglobulin domains, the CH2 domain has the lowest thermal stability, which also depends on amino acid sequence and buffer conditions. To......

Multiple sites on SARS-CoV-2 spike protein are susceptible to proteolysis by cathepsins B, K, L, S, and V

期刊: PROTEIN SCIENCE, 2021; 30 (6)

SARS-CoV-2 is the coronavirus responsible for the COVID-19 pandemic. Proteases are central to the infection process of SARS-CoV-2. Cleavage of the spi......

Dynamically probing ATP-dependent RNA helicase A-assisted RNA structure conversion using single molecule fluorescence resonance energy transfer

期刊: PROTEIN SCIENCE, 2021; 30 (6)

RNA helicase A (RHA) as a member of DExH-box subgroup of helicase superfamily II, participates in diverse biological processes involved in RNA metabol......

Cardiolipin interacts with beta-2-glycoprotein I and forms an open conformation-Mechanisms analyzed using hydrogen/deuterium exchange

期刊: PROTEIN SCIENCE, ; ()

Beta-2-glycoprotein I (beta(2)GPI) is the major antigen for the antiphospholipid antibodies in the antiphospholipid syndrome. The exposed epitope in d......

Sandwiched-fusion strategy facilitates recombinant production of small labile proteins

期刊: PROTEIN SCIENCE, 2021; 30 (3)

Efficient production of large quantities of soluble, properly folded proteins is of high demand in modern structural and functional genomics. Despite ......

Nonstructural protein 7 and 8 complexes of SARS-CoV-2

期刊: PROTEIN SCIENCE, 2021; 30 (4)

The pandemic outbreak of coronavirus disease 2019 (COVID-19) across the world has led to millions of infection cases and caused a global public health......

The mechanism of Single strand binding protein-RecG binding: Implications for SSB interactome function

期刊: PROTEIN SCIENCE, 2020; 29 (5)

The Escherichia coli single-strand DNA binding protein (SSB) is essential to viability where it functions to regulate SSB interactome function. Here i......

Atg3 promotes Atg8 lipidation via altering lipid diffusion and rearrangement

期刊: PROTEIN SCIENCE, 2020; 29 (6)

Atg3-catalyzed transferring of Atg8 to phosphatidylethanolamine (PE) in the phagophore membrane is essential for autophagy. Previous studies have demo......

Single-particle analysis of urea amidolyase reveals its molecular mechanism

期刊: PROTEIN SCIENCE, 2020; 29 (5)

Urea amidolyase (UA), a bifunctional enzyme that is widely distributed in bacteria, fungi, algae, and plants, plays a pivotal role in the recycling of......

Structural and biochemical characterization of SADS-CoV papain-like protease 2

期刊: PROTEIN SCIENCE, 2020; 29 (5)

Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel coronavirus that is involved in severe diarrhea disease in piglets, causing considerab......

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