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YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (7)

Aberrant expression of kinesin family member 4A (KIF4A), which is associated with tumor progression, has been reported in several types of cancer. How......

Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (10)

ERCC1 is a gene for repairing DNA damage whose function is related to carcinogenic-induced tumorigenesis and the effectiveness of platinum therapies. ......

HET0016 attenuates the stemness of breast cancer cells through targeting CYP4Z1

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (6)

Ours and other previous studies have shown that CYP4Z1 is specifically and highly expressed in breast cancer, and acts as a promoter for the stemness ......

ALKBH5-mediated m6A-demethylation of USP1 regulated T-cell acute lymphoblastic leukemia cell glucocorticoid resistance by Aurora B

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (9)

Recent studies evidence that ubiquitin-specific proteases (USPs) are associated with the occurrence and chemoresistance of T-cell acute lymphoblastic ......

Blocking MCT4 SUMOylation inhibits the growth of breast cancer cells

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (10)

Monocarboxylate transporter 4 (MCT4) is highly expressed in various types of solid neoplasms including breast cancer (BC); however, the pro-tumor func......

Autophagy modulates FSS-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (9)

Hepatocellular carcinoma is a highly fatal disease and threatens human health seriously. Fluid shear stress (FSS), which is caused by the leakage of p......

Feed-forward activation of STAT3 signaling limits the efficacy of c-Met inhibitors in esophageal squamous cell carcinoma (ESCC) treatment

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (7)

c-Hepatocyte growth factor receptor (Met) inhibitors have demonstrated clinical benefits in some types of solid tumors. However, the efficacy of c-Met......

miR-506-loaded gelatin nanospheres target PENK and inactivate the ERK/Fos signaling pathway to suppress triple-negative breast cancer aggressiveness

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (8)

Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. Some microRNAs (miRNAs) were abnormally expressed in TNBC, and th......

Effects of genetic polymorphisms in INTS10 and their interaction with environmental factors on progression from persistent HBV infection to hepatocellular carcinoma

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (9)

Genome-wide association study recently identified a novel antiviral gene INTS10 (index rs7000921) in suppression of hepatitis B virus (HBV) replicatio......

The LncRNA FGD5-AS1/miR-497-5p axis regulates septin 2 (SEPT2) to accelerate cancer progression and increase cisplatin-resistance in laryngeal squamous cell carcinoma

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (7)

Aberrant expression or mutation of the Septin gene family is closely associated with cancer progression, and septin 2 (SEPT2) exerts its tumor-promoti......

CircSPAG16 suppresses cadmium-induced transformation of human bronchial epithelial cells by decoying PIP5K1 alpha to inactivate Akt

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (8)

Circular RNAs (circRNAs) have been implicated to have important regulatory functions in chemical carcinogenesis via sponging microRNAs to regulate gen......

H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (8)

Tumour-derived CXCL8 facilitates the movement of myeloid-derived suppressor cells, which are able to restrain antitumour immune responses to the tumou......

Development and validation of 3-CpG methylation prognostic signature based on different survival indicators for colorectal cancer

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (6)

Abnormal DNA methylation is considered a vital hallmark to regulate gene expression and influence the development and progression of colorectal cancer......

CMTM4 regulates epithelial-mesenchymal transition and PD-L1 expression in head and neck squamous cell carcinoma

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (8)

The epithelial-mesenchymal transition (EMT) is a pivotal step involved in cancer recurrence and metastasis. In addition, the activation of the EMT pro......

Association of genetic variants of FBXO32 and FOXO6 in the FOXO pathway with breast cancer risk

期刊: MOLECULAR CARCINOGENESIS, 2021; 60 (10)

Forkhead box class O (FOXO) transcription factors play a pivotal role in regulating a variety of biological processes, including organismal developmen......

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