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Allylic alcohol synthesis by Ni-catalyzed direct and selective coupling of alkynes and methanol

期刊: CHEMICAL SCIENCE, 2021; 12 (27)

Methanol is an abundant and renewable chemical raw material, but its use as a C1 source in C-C bond coupling reactions still constitutes a big challen......

Atroposelective synthesis of N-aryl peptoid atropisomers via a palladium(ii)-catalyzed asymmetric C-H alkynylation strategy

期刊: CHEMICAL SCIENCE, 2021; 12 (27)

The introduction of chirality into peptoids is an important strategy to determine a discrete and robust secondary structure. However, the lack of an e......

Me3SiSiMe2((OBu)-Bu-n): a disilane reagent for the synthesis of diverse silacycles via Brook- and retro-Brook-type rearrangement

期刊: CHEMICAL SCIENCE, 2021; 12 (35)

Herein, a readily available disilane Me3SiSiMe2((OBu)-Bu-n) has been developed for the synthesis of diverse silacycles via Brook- and retro-Brook-type......

Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles

期刊: CHEMICAL SCIENCE, 2021; 12 (12)

Copper complexes are promising anticancer agents widely studied to overcome tumor resistance to metal-based anticancer drugs. Nevertheless, copper com......

Construction of diverse peptide structural architectures via chemoselective peptide ligation

期刊: CHEMICAL SCIENCE, 2021; 12 (20)

Herein, we report the development of a facile synthetic strategy for constructing diverse peptide structural architectures via chemoselective peptide ......

Enantioselective hydrogenation of annulated arenes: controlled formation of multiple stereocenters in adjacent rings

期刊: CHEMICAL SCIENCE, 2021; 12 (15)

We report a method for the enantioselective hydrogenation of annulated arenes using 4H-pyrido[1,2-a]pyrimidinones as substrates. The method selectivel......

Recent advances in single atom catalysts for the electrochemical carbon dioxide reduction reaction

期刊: CHEMICAL SCIENCE, 2021; 12 (20)

The electrochemical carbon dioxide reduction reaction (CO2RR) offers a promising solution to mitigate carbon emission and at the same time generate va......

DNA nanostructure-based nucleic acid probes: construction and biological applications

期刊: CHEMICAL SCIENCE, 2021; 12 (22)

In recent years, DNA has been widely noted as a kind of material that can be used to construct building blocks for biosensing, in vivo imaging, drug d......

Fluorescence detected circular dichroism (FDCD) for supramolecular host-guest complexes

期刊: CHEMICAL SCIENCE, 2021; 12 (27)

Fluorescence-detected circular dichroism (FDCD) spectroscopy is applied for the first time to supramolecular host-guest and host-protein systems and c......

Copper-catalyzed asymmetric cyclization of alkenyl diynes: method development and new mechanistic insights

期刊: CHEMICAL SCIENCE, 2021; 12 (27)

Metal carbenes have proven to be one of the most important and useful intermediates in organic synthesis, but catalytic asymmetric reactions involving......

Enantioselective total synthesis of parnafungin A1 and 10a-epi-hirtusneanine

期刊: CHEMICAL SCIENCE, 2021; 12 (30)

The first and enantioselective total synthesis of the heterodimeric biaryl antifungal natural product parnafungin A1 as well as complex biaryl tetrahy......

Chirality memory of alpha-methylene-pi-allyl iridium species

期刊: CHEMICAL SCIENCE, 2021; 12 (35)

Chirality is one of the most important types of steric information in nature. In addition to central chirality, axial chirality has been catching more......

Nickel-catalyzed asymmetric reductive arylation of alpha-chlorosulfones with aryl halides

期刊: CHEMICAL SCIENCE, 2021; 12 (14)

We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic alpha -chlorosulfones to afford enantioenriched ......

Micrometer-scale transient ion transport for real-time pH assay in living rat brains

期刊: CHEMICAL SCIENCE, 2021; 12 (21)

Ion transport has been widely used for various applications such as sensing, desalination and energy conversion; however, nearly all applications are ......

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