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Mitochondrial dysfunction and potential mitochondrial protectant treatments in tendinopathy

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2021; 1490 (1)

Tendinopathy is a common musculoskeletal condition that affects a wide range of patients, including athletes, laborers, and older patients. Tendinopat......

The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F......

Extracellular vesicles from M1-polarized macrophages promote inflammation in the temporomandibular joint via miR-1246 activation of the Wnt/beta-catenin pathway

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Macrophage-mediated regulation of chondrocytes plays an important role in promoting temporomandibular joint (TMJ) inflammation. We investigated whethe......

Symptomatic spinal cord compression: an uncommon symptom in pseudohypoparathyroidism

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

We describe symptomatic spinal cord compression associated with pseudohypoparathyroidism (PHP) in a young female patient and reviewed similar cases pr......

Movement-induced hypoalgesia: behavioral characteristics and neural mechanisms

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Pain is essential for our survival because it helps to protect us from severe injuries. Nociceptive signals may be exacerbated by continued physical a......

Genomic insights into evolution of pathogenicity and resistance of multidrug-resistant Raoultella ornithinolytica WM1

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Raoultella ornithinolytica is a poorly understood opportunistic pathogen, and the underlying mechanisms of its multidrug resistance and pathogenicity ......

Approaches for the integration of big data in translational medicine: single-cell and computational methods

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Translational medicine describes a bench-to-bedside approach that eventually converts findings from basic scientific studies into real-world clinical ......

A novel fully immersive virtual reality environment for upper extremity rehabilitation in patients with stroke

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Given the rising incidence of stroke, several technology-driven methods for rehabilitation have recently been developed. Virtual reality (VR) is a pro......

China's antenatal care promoting early childhood development: evidence from a cross-sectional survey

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

The Chinese government has established a three-tier maternal care system covering the entire country and providing integrated antenatal care (ANC) for......

Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

The purpose of this study was to investigate the possible use of resveratrol (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that o......

Progranulin promotes bone fracture healing via TNFR pathways in mice with type 2 diabetes mellitus

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, ; ()

Type 2 diabetes mellitus (T2DM) significantly increases bone fragility and fracture risk. Progranulin (PGRN) promotes bone fracture healing in both ph......

Selected updates in molecular and genomic pathology of esophageal cancer

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020; 1482 (1)

Recent years have seen rapid advances in the field of molecular and genomic pathology that have not only improved understanding of esophageal carcinog......

Betulinic acid restores imatinib sensitivity in BCR-ABL1 kinase-independent, imatinib-resistant chronic myeloid leukemia by increasing HDAC3 ubiquitination and degradation

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020; 1467 (1)

Although imatinib (IM) has been demonstrated to be an efficient treatment in chronic myeloid leukemia (CML), some patients still experience IM resista......

Molecular regulation of autophagy machinery by mTOR-dependent and -independent pathways

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020; 1467 (1)

Macroautophagy is a lysosomal degradative pathway or recycling process that maintains cellular homeostasis. This autophagy involves a series of sequen......

Establishment and evolution of heterochromatin

期刊: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020; 1476 (1)

The eukaryotic genome is packaged into transcriptionally active euchromatin and silent heterochromatin, with most studies focused on the former encomp......

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