期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 211 ()
Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Her......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 215 ()
Currently, SARS-CoV-2 virus is an emerging pathogen that has posed a serious threat to public health worldwide. However, no agents have been approved ......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 220 ()
Y Factor XIa, as a blood coagulation enzyme, amplifies the generation of the last enzyme thrombin in the blood coagulation cascade. It was proved that......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 212 ()
Lysine crotonylation plays vital roles in gene transcription and cellular metabolism. Nevertheless, methods for dissecting the molecular mechanisms of......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 215 ()
In this study, a series of pyrrolo [2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment were synthesized and their biological act......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 216 ()
Recent research has indicated that the abnormal expression of the deubiquitinase USP7 induces tumorigenesis via multiple cell pathways, and in particu......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 222 ()
The catalytic properties of small-molecule proteolysis targeting chimeras (PROTACs) may lead to uncontrolled degradation. Therefore, the main disadvan......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 222 ()
Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery directed at histone epigenetic modulators has gained impressiv......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 212 ()
Current drugs available in clinic for Alzheimer's disease (AD) treatment can only alleviate disease symptoms without clearly curing or delaying the pr......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 212 ()
Inhibition of the soluble epoxide hydrolase (sEH) is a promising new therapeutic approach in the treatment of inflammation. Driven by the in-house dat......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 218 ()
Signal transducer and activator of transcription 3 (STAT3) has been confirmed as an attractive therapeutic target for cancer therapy. Herein, we desig......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 219 ()
Isosteviol, an ent-beyerane diterpenoid, has been repeatedly reported to possess potent cardioprotective activity. With the aim of discovering new car......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 219 ()
Research to develop active dendrimers by themselves or as nanocarriers represents a promising approach to discover new biologically active entities th......
期刊： EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 219 ()
The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E pl......
