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The Coxiella burnetii QpH1 Plasmid Is a Virulence Factor for Colonizing Bone Marrow-Derived Murine Macrophages

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (9)

Coxiella burnetii strains carry one of four large, conserved, autonomously replicating plasmids (QpH1, QpRS, QpDV, or QpDG) or a QpRS-like chromosomal......

Structural Insight into the Role of the PAS Domain for Signal Transduction in Sensor Kinase BvgS

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (9)

The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine kinases h......

An Extracytoplasmic Function Sigma/Anti-Sigma Factor System Regulates Hypochlorous Acid Resistance and Impacts Expression of the Type IV Secretion System in Brucella melitensis

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (12)

The intracellular bacterial pathogen Brucella causes persistent infections in various mammalian species. To survive and replicate within macrophages, ......

The LysR-Type Transcriptional Regulator CrgA Negatively Regulates the Flagellar Master Regulator flhDC in Ralstonia solanacearum GMI1000

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (1)

The invasion and colonization of host plants by the destructive pathogen Ralstonia solanacearum rely on its cell motility, which is controlled by mult......

Gut Microbiota: the Emerging Link to Lung Homeostasis and Disease

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (4)

The gut microbiota plays a crucial role in the development of the immune system and confers benefits or disease susceptibility to the host. Emerging s......

Functional Characterization of the gamma-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC2 155 Reveals Sodium-Driven GABA Transport

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (4)

Characterizing the mycobacterial transporters involved in the uptake and/or catabolism of host-derived nutrients required by mycobacteria may identify......

TK1211 Encodes an Amino Acid Racemase towards Leucine and Methionine in the Hyperthermophilic Archaeon Thermococcus kodakarensis

期刊: JOURNAL OF BACTERIOLOGY, 2021; 203 (7)

Members of Thermococcales harbor a number of genes encoding putative aminotransferase class III enzymes. Here, we characterized the TK1211 protein fro......

A Membrane-Bound Transcription Factor is Proteolytically Regulated by the AAA plus Protease FtsH in Staphylococcus aureus

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (9)

In bacteria, chromosomal DNA resides in the cytoplasm, and most transcription factors are also found in the cytoplasm. However, some transcription fac......

Increased Excess Intracellular Cyclic di-AMP Levels Impair Growth and Virulence of Bacillus anthracis

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (9)

Cyclic di-AMP (c-di-AMP) is a recently identified bacterial second messenger that regulates biological processes. In this study, we found that inactiv......

Fis Contributes to Resistance of Pseudomonas aeruginosa to Ciprofloxacin by Regulating Pyocin Synthesis

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (11)

Factor for inversion stimulation (Fis) is a versatile DNA binding protein that plays an important role in coordinating bacterial global gene expressio......

Genetic Analysis of Mutacin B-Ny266, a Lantibiotic Active against Caries Pathogens

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (12)

Bacteriocins are ribosomally synthesized proteinaceous antibacterial peptides. They selectively interfere with the growth of other bacteria. The produ......

Global Regulatory Roles of the Histidine-Responsive Transcriptional Repressor HutC in Pseudomonas fluorescens SBW25

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (13)

HutC is known as a transcriptional repressor specific for histidine utilization (hut) genes in Gram-negative bacteria, including Pseudomonas fluoresce......

ATP Binding as a Key Target for Control of the Chemotaxis Kinase

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (13)

In bacterial chemotaxis, chemoreceptors in signaling complexes modulate the activity of two-component histidine kinase CheA in response to chemical st......

Context-Dependent Action of Scc4 Reinforces Control of the Type III Secretion System

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (15)

Chlamydia trachomatis Scc4 (formerly CT663) engages the transcription machinery and the pathogenic type III secretion system (T3SS). Both machines are......

Roles of the Site 2 Protease Eep in Staphylococcus aureus

期刊: JOURNAL OF BACTERIOLOGY, 2020; 202 (15)

In Enterococcus faecalis, the site 2 protease Eep generates sex phero-mones, including cAM373. Intriguingly, in Staphylococcus aureus, a peptide simil......

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