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Biological functions of NLRP3 inflammasome: A therapeutic target in inflammatory bowel disease

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2021; 60 ()

Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex pathological mechanisms, have been increasing in recent yea......

The roles and potential therapeutic implications of C5a in the pathogenesis of COVID-19-associated coagulopathy

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2021; 58 ()

Emerging evidence has documented that multisystem organ failure in coronavirus disease 2019 (COVID-19) patients is strongly associated with various co......

When Rab GTPases meet innate immune signaling pathways

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2021; 59 ()

Ras-related protein in brain (Rab) GTPases, the subfamily of small GTP-binding proteins superfamily, play a vital role in regulating and controlling v......

Cytokines in oncolytic virotherapy

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 56 ()

Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ......

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 53 ()

The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) responsible for coronavirus disease 2019 (COVID-19) has develop......

Cytokine storm intervention in the early stages of COVID-19 pneumonia

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 53 ()

Clinical intervention in patients with corona virus disease 2019 (COVID-19) has demonstrated a strong upregulation of cytokine production in patients ......

Selective inhibition of Tumor necrosis factor receptor-1 (TNFR1) for the treatment of autoimmune diseases

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 55 ()

Anti-TNF biologics have achieved great success in the treatment of autoimmune diseases and have been the most selling biologics on market. However, th......

Protein arginine methylation promotes therapeutic resistance in human pancreatic cancer

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 55 ()

Pancreatic cancer is a lethal disease with limited treatment options for cure. A high degree of intrinsic and acquired therapeutic resistance may resu......

Interferon regulatory factor 8 governs myeloid cell development

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 55 ()

Interferon regulatory factors (IRFs) are a family of central transcriptional regulators that produce type I interferon and regulate innate and adaptiv......

The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 52 ()

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with menopause-related estrogen withdrawal. PMOP is characterized by lo......

Molecular characteristics and possible functions of innate lymphoid cells in the uterus and gut

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 52 ()

With the discovery of innate lymphoid cells (ILCs), which are especially enriched in barrier surfaces, the family of innate lymphocytes has grown. A u......

The expression and immunoregulation of immune checkpoint molecule VISTA in autoimmune diseases and cancers

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2020; 52 ()

Immune checkpoint inhibitors (ICIs) and immunotherapy have proven to be a transformative therapy for many forms of cancer treatment. While many antibo......

Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2019; 45 ()

Progranulin (PGRN), a widely expressed glycoprotein with pleiotropic function, has been linked to a host of physiological processes and diverse pathol......

JIF:5.46

Recent advances in the biology of IL-1 family cytokines and their potential roles in development of sepsis

期刊: CYTOKINE & GROWTH FACTOR REVIEWS, 2019; 45 ()

The IL-1 family comprises two anti-inflammatory cytokines (IL-37, IL-38), two receptor antagonists (IL-1ra, IL-36ra), and seven ligand agonists (IL-1 ......

JIF:5.46

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