筛选条件 共查询到87条结果
排序方式
Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2021; 20 (2)

Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated ......

BDNF-TrkB and proBDNF-p75(NTR)/Sortilin Signaling Pathways are Involved in Mitochondria-Mediated Neuronal Apoptosis in Dorsal Root Ganglia after Sciatic Nerve Transection

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (1)

Background: Brain-Derived Neurotrophic Factor (BDNF) plays critical roles during development of the central and peripheral nervous systems, as well as......

Pharmacokinetics and Acute Toxicity of a Histone Deacetylase Inhibitor, Scriptaid, and its Neuroprotective Effects in Mice After Intracranial Hemorrhage

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (1)

Background & Objective: The pharmacokinetics and acute toxicity of a histone deacetylase inhibitor, Scriptaid, was unknown in the mouse. The aim o......

Targeting the PI3K/AKT/mTOR Signaling Pathway in Primary Central Nervous System Lymphoma: Current Status and Future Prospects

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (3)

Primary Central Nervous System Lymphoma (PCNSL) is a rare invasive extranodal non-Hodgkin lymphoma, a vast majority of which is Diffuse Large B-Cell L......

Metabolic Adjustments by LncRNAs in Peripheral Neutrophils Partly Account for the Complete Compensation of Asymptomatic MMD Patients

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (4)

Background: Due to the recent development of non-invasive examinations, more asymptomatic patients with Moyamoya Disease (MMD) have been diagnosed tha......

Yishen Huazhuo Decoction Induces Autophagy to Promote the Clearance of A beta(1-42) in SAMP8 Mice: Mechanism Research of a Traditional Chinese Formula Against Alzheimer's Disease

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (4)

Background: Studies have found that autophagy could promote the clearance of A beta. To promote and maintain the occurrence of autophagy in Alzheimer'......

MAPK: A Key Player in the Development and Progression of Stroke

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (4)

Stroke is a complex disease caused by genetic and environmental factors, and its etiological mechanism has not been fully clarified yet, which brings ......

The MMP-2/TIMP-2 System in Alzheimer Disease

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (6)

Alzheimer Disease (AD) is the most prevalent type of dementia. Pathological changes in the All brain include Amyloid beta-protein (A beta) plaques and......

Microbiota-Immune System Interactions in Human Neurological Disorders

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (7)

Recent studies implicate microbiota-brain communication as an essential factor for physiology and pathophysiology in brain function and neurodevelopme......

Minocycline Inhibits mTOR Signaling Activation and Alleviates Behavioral Deficits in the Wistar Rats with Acute Ischemia stroke

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2020; 19 (10)

Background: Mammalian target of rapamycin (mTOR) has been evidenced as a multi-modal therapy in the pathophysiological process of Acute Ischemic Strok......

A Novel Botulinum Toxin TAT-EGFP-HCS Fusion Protein Capable of Specific Delivery Through the Blood-brain Barrier to the Central Nervous System

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2019; 18 (1)

Objective: Botulinum toxin has many applications in the treatment of central diseases, as biological macromolecules, it is difficult to pass through t......

JIF:2.76

Xuesaitong May Protect Against Ischemic Stroke by Modulating Microglial Phenotypes and Inhibiting Neuronal Cell Apoptosis via the STAT3 Signaling Pathway

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2019; 18 (2)

Background: Xuesaitong mainly comprises Panax notoginseng saponins and has shown a promising feature in an acute ischemic stroke model; however, its e......

JIF:2.76

A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2019; 18 (2)

Background & Objective: Alzheimer's disease (AD) and Parkinson's disease (PD) affect an increasing number of the elderly population worldwide. The......

JIF:2.76

Fire Needle Acupuncture Regulates Wnt/ERK Multiple Pathways to Promote Neural Stem Cells to Differentiate into Neurons in Rats with Spinal Cord Injury

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2019; 18 (3)

Background & Objective: NSCs therapy is considered one of the most potential methods for spinal cord injury (SCI). Methods: We build the SCI model......

JIF:2.76

Noncoding RNAs and Intracerebral Hemorrhage

期刊: CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2019; 18 (3)

Background & Objective: Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, for which there are few effective interventions.......

JIF:2.76

共87条页码: 1/6页15条/页