筛选条件 共查询到398条结果
排序方式
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells

期刊: TOXICOLOGY, 2021; 454 ()

Great attention has been paid to 1,3-dichloro-2-propanol (1,3-DCP) due to its presence in food and concerns about toxic potential as carcinogens. In o......

Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A

期刊: TOXICOLOGY, 2021; 455 ()

Bisphenol A (BPA) is recognized as a harmful pollutant in the worldwide. Growing studies have reported that BPA can cause adverse effects and diseases......

The efficacy and toxicity of antineoplastic antimetabolites: Role of gut microbiota

期刊: TOXICOLOGY, 2021; 460 ()

The incidence and mortality of cancer are rapidly growing all over the world. Nowadays, antineoplastic antimetabolites still play a key role in the ch......

3,5,6-trichloro-2-pyridinol intensifies the effect of chlorpyrifos on the paracrine function of Sertoli cells by preventing binding of testosterone and the androgen receptor

期刊: TOXICOLOGY, 2021; 460 ()

3,5,6-Trichloro-2-pyridinol (TCP) is an important biomarker and one of the final metabolites of chlorpyrifos (CPF). TCP inhibits secretion of sex horm......

Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1 alpha pathway

期刊: TOXICOLOGY, 2021; 451 ()

Objective: This study was aimed to explore the possible mechanism of environmental metal cadmium (Cd) inducing apoptosis of pig lymph nodes. Method: 1......

Changes induced by chronic exposure to high arsenic concentrations in the intestine and its microenvironment

期刊: TOXICOLOGY, 2021; 456 ()

The perturbation of intestinal microbes may serve as a mechanism by which arsenic exposure causes or exacerbates diseases in humans. However, the chan......

Nuclear factor erythroid 2-related factor 2 potentiates the generation of inflammatory cytokines by intestinal epithelial cells during hyperoxia by inducing the expression of interleukin 17D

期刊: TOXICOLOGY, 2021; 457 ()

Prolonged exposure to therapeutic hyperoxia can induce severe side effects on intestinal epithelial cells. Meanwhile, interleukin (IL)-17D secreted by......

Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro

期刊: TOXICOLOGY, 2021; 460 ()

Myocardial apoptosis and necroptosis are the major etiological factor during doxorubicin (DOX) induced cardiotoxicity, and one of the important reason......

Multidrug resistance-associated protein 2 is negatively regulated by oxidative stress in rat intestine via a posttranslational mechanism. Impact on its membrane barrier function

期刊: TOXICOLOGY, 2021; 460 ()

Oxidative stress (OS) is a key factor in the development of gastrointestinal disorders, in which the intestinal barrier is altered. However, the Multi......

Perfluorodecanoic acid induces meiotic defects and deterioration of mice oocytes in vitro

期刊: TOXICOLOGY, 2021; 460 ()

Perfluorodecanoic acid (PFDA) is a member of the perfluoroalkyl substances, which are toxic to organic functions. Recently, it has been found in folli......

Role of estrogen receptor alpha in MEHP-induced proliferation and invasion of SH-SY5Y cells

期刊: TOXICOLOGY, 2021; 453 ()

Estrogen receptors are involved in regulating the proliferation and invasion process of neuroblastoma. As a kind of estrogen-like environmental endocr......

Metabolomics analysis underlay mechanisms in the renal impairment of mice caused by combination of aflatoxin M1 and ochratoxin A

期刊: TOXICOLOGY, 2021; 458 ()

Aflatoxin M1 (AFM1) and ochratoxin A (OTA) are pernicious mycotoxins widely co-existing in the environment. However, nephrotoxicity and underlying mec......

L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity

期刊: TOXICOLOGY, 2021; 459 ()

Oxaliplatin (OXA) is a third-generation platinum drug; however, its application is greatly limited due to the severe peripheral neurotoxicity. This st......

Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum

期刊: TOXICOLOGY, 2021; 459 ()

Cadmium (Cd) is a toxic heavy metal that accumulates in the brain and causes a series of histopathological changes. Selenium (Se) exerts a crucial fun......

Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum

期刊: TOXICOLOGY, 2021; 453 ()

Cisplatin-induced ototoxicity is one of the important reasons that limit the drug's clinical application, and its mechanism has not been fully elucida......

共398条页码: 1/27页15条/页