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Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin

期刊: EMBO JOURNAL, 2021; 40 (16)

Pangolins have been suggested as potential reservoir of zoonotic viruses, including SARS-CoV-2 causing the global COVID-19 outbreak. Here, we study th......

ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6

期刊: EMBO JOURNAL, 2021; 40 (16)

Excessive deposition of extracellular matrix, mainly collagen protein, is the hallmark of organ fibrosis. The molecular mechanisms regulating fibrotic......

Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans

期刊: EMBO JOURNAL, 2021; 40 (13)

Current understanding holds that Klinefelter syndrome (KS) is not inherited, but arises randomly during meiosis. Whether there is any genetic basis fo......

Gut inflammation triggers C/EBP beta/delta-secretase-dependent gut-to-brain propagation of A beta and Tau fibrils in Alzheimer's disease

期刊: EMBO JOURNAL, 2021; 40 (17)

Inflammation plays an important role in the pathogenesis of Alzheimer's disease (AD). Some evidence suggests that misfolded protein aggregates found i......

Sphingosine-1-phosphate: The missing link between NOD1/2 and ER stress

期刊: EMBO JOURNAL, 2021; 40 (13)

The cytosolic NOD1 and NOD2 pattern recognition receptors are typically known as sensors of bacterial peptidoglycan fragments. A new study in this iss......

Inhibition of Syk promotes chemical reprogramming of fibroblasts via metabolic rewiring and H2S production

期刊: EMBO JOURNAL, 2021; 40 (11)

Chemical compounds have recently been introduced as alternative and non-integrating inducers of pluripotent stem cell fate. However, chemical reprogra......

A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6 bodies

期刊: EMBO JOURNAL, 2021; 40 (15)

Selective autophagy mediates specific degradation of unwanted cytoplasmic components to maintain cellular homeostasis. The suppressor of gene silencin......

SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

期刊: EMBO JOURNAL, 2021; 40 (18)

SARS-CoV-2 is an emerging coronavirus that causes dysfunctions in multiple human cells and tissues. Studies have looked at the entry of SARS-CoV-2 int......

Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1

期刊: EMBO JOURNAL, 2021; 40 (15)

In selective autophagy, cargo selectivity is determined by autophagy receptors. However, it remains scarcely understood how autophagy receptors recogn......

Barley stripe mosaic virus gamma b protein disrupts chloroplast antioxidant defenses to optimize viral replication

期刊: EMBO JOURNAL, 2021; 40 (16)

The plant antioxidant system plays important roles in response to diverse abiotic and biotic stresses. However, the effects of virus infection on host......

Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate

期刊: EMBO JOURNAL, 2021; 40 (13)

Cellular stress has been associated with inflammation, yet precise underlying mechanisms remain elusive. In this study, various unrelated stress induc......

ATP and cancer immunosurveillance

期刊: EMBO JOURNAL, 2021; 40 (13)

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic metabolism of all the cellular compartments that form the......

The DnaJ proteins DJA6 and DJA5 are essential for chloroplast iron-sulfur cluster biogenesis

期刊: EMBO JOURNAL, 2021; 40 (13)

Fe-S clusters are ancient, ubiquitous and highly essential prosthetic groups for numerous fundamental processes of life. The biogenesis of Fe-S cluste......

The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation

期刊: EMBO JOURNAL, 2021; 40 (11)

The ongoing outbreak of severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) demonstrates the continuous threat of emerging coronavirus......

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