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Knockdown of LINC02465 Suppresses Gastric Cancer Cell Growth and Metastasis Via PI3K/AKT Pathway

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (1)

Gastric cancer (GC) is the second primary cause of cancer-associated mortality around the world. Long noncoding RNAs (lncRNAs) are critical modulators......

JIF:2.78

In Vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Malignant Melanoma

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (1)

Malignant melanoma is an aggressive tumor with high fatality rates and poor prognosis, mainly due to the lack of efficient treatment methods. The pres......

JIF:2.78

Upregulation of DNA Metabolism-Related Genes Contributes to Radioresistance of Glioblastoma

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (2)

Glioblastomas (GBMs) are the most prevalent brain tumor and exhibit poor prognosis. Radiotherapy is an important strategy for GBMs patients; however, ......

JIF:2.78

miR-632 Functions as Oncogene in Hepatocellular Carcinoma via Targeting MYCT1

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (2)

microRNAs (miRNAs) have been widely recognized as crucial regulators for tumorigenesis. However, the role of miR-632 in hepatocellular carcinoma (HCC)......

JIF:2.78

MiR-625-5p Inhibits Cardiac Hypertrophy Through Targeting STAT3 and CaMKII

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (4)

Cardiac hypertrophy is an adaptive cardiac response to heart stress. Sustained cardiac hypertrophy indicates higher risk of heart failure. Ca2+/calmod......

JIF:2.78

Inhibition of miR-203 Ameliorates Osteoarthritis Cartilage Degradation in the Postmenopausal Rat Model: Involvement of Estrogen Receptor alpha

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (4)

miR-203 is known to target estrogen receptor alpha (ER alpha) in various cancer cell lines, such as MCF-7. However, whether miR-203 regulates ER alpha......

JIF:2.78

Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (4)

Hepatocellular carcinoma (HCC) is the most common malignancy in liver and is one of the leading causes of cancer-induced deaths all over the world. Ci......

JIF:2.78

MicroRNA-4513 Promotes Gastric Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Targeting KAT6B

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (3)

The purpose of this study was to investigate the expression level of microRNA-4513 (miR-4513) in gastric cancer (GC), and to elucidate the mechanisms ......

JIF:2.78

LncRNA HOXA-AS3 Sponges miR-29c to Facilitate Cell Proliferation, Metastasis, and EMT Process and Activate the MEK/ERK Signaling Pathway in Hepatocellular Carcinoma

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2019; 30 (3)

Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with high morbidity and mortality across the world. Recent findings have suggested that ......

JIF:2.78

MiRNA-451 Inhibits Glioma Cell Proliferation and Invasion Through the mTOR/HIF-1 alpha/VEGF Signaling Pathway by Targeting CAB39

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2018; 29 (3)

MicroRNAs (miRNAs) are widely expressed and regulate most biological functions. According to several research groups, miR-451 expression is decreased ......

JIF:2.78

Establishing China's National Standard for the Recombinant Adenovirus Type 5 Vector-Based Ebola Vaccine (Ad5-EBOV) Virus Titer

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2018; 29 (4)

The 2014 Ebola outbreak in West Africa brought great threat to public health worldwide. There was no approved antiviral therapy or vaccine available t......

JIF:2.78

Varinostat Alters Gene Expression Profiles in Aortic Tissues from ApoE(-/-) Mice

期刊: HUMAN GENE THERAPY CLINICAL DEVELOPMENT, 2018; 29 (4)

Atherosclerosis (AS) is a complex, chronic inflammatory disease that is characterized by plaque buildup within arterial vessel walls. Preclinical tria......

JIF:2.78

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