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The role of AMP-activated protein kinase alpha 1-mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2021; 41 (9)

Recently, the Klotho protein (Klotho) has received substantial attention as protective factor against cardiovascular complications of chronic kidney d......

Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE(-/-) mouse model

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2021; 41 (10)

Cigarette smoking is one major modifiable risk factor in the development and progression of chronic obstructive pulmonary disease and cardiovascular d......

In silico prediction of mitochondrial toxicity of chemicals using machine learning methods

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2021; 41 (10)

Mitochondria are important organelles in human cells, providing more than 95% of the energy. However, some drugs and environmental chemicals could ind......

Toxicity evaluation of mesoporous silica particles Santa Barbara No. 15 amorphous in human umbilical vein endothelial cells: influence of particle morphology

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Morphology plays a vital role in determining the biological effects of silica nanoparticles (NPs), but its influence on the toxicity of silica NPs in ......

Cardiotoxicity induced by Cochinchina momordica seed extract in zebrafish

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Momordica cochinchinensis (Lour.) Spreng is an indigenous South Asian edible fruit, and seeds of Momordica cochinchinensis have been used therapeutica......

Research progress on the carcinogenicity of metal nanomaterials

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

With the rapid development of nanotechnology, new nanomaterials with enormous potentials continue to emerge, especially metal nanomaterials. Metal nan......

Profiling gene expression reveals insights into pulmonary response to aerosolized botulinum toxin type A exposure in mice

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Botulinum neurotoxin type A (BoNT/A) is traditional medicine and well known for its therapeutic use as an anesthetic and in cosmetic applications that......

SiO2 stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Silicosis is a serious occupational disease with the highest incidence in China. However, its pathogenesis has not been fully elucidated. Studies have......

The effect of combined exposure of zinc and nickel on the development of zebrafish

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Excessive accumulation of Zn2+ or Ni2+ can cause various problems to aquatic animals. In this study, the developmental toxicity induced by individual ......

Spectrochemical determination of effects on rat liver of binary exposure to benzo[a]pyrene and 2,2 ',4,4 '-tetrabromodiphenyl ether

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Benzo[a]pyrene (B[a]P) and polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants. The effects in organisms of exposures to ......

Acute and subacute inhalation toxicity assessment of WS-23 in Sprague-Dawley rats

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

2-isopropyl-N,2,3-trimethylbutyramide (WS-23) is a well-known artificial synthesis cooling agent widely used in foods, medicines, and tobaccos. As a c......

Cytotoxicity and inflammatory effects in human bronchial epithelial cells induced by polycyclic aromatic hydrocarbons mixture

期刊: JOURNAL OF APPLIED TOXICOLOGY, ; ()

Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in the air pollutants. Inhalation exposure to PAHs could increase the risk of......

The toxicity of ambient fine particulate matter (PM2.5) to vascular endothelial cells

期刊: JOURNAL OF APPLIED TOXICOLOGY, 2021; 41 (5)

Several epidemiologic and toxicological studies have widely regarded ambient fine particulate matter (PM2.5), the particles with an aerodynamic diamet......

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