期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (3)
Group B Streptococcus (GBS) remains the most common Gram-positive bacterium causing neonatal meningitis and GBS meningitis continues to be an importan......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (2)
Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co-agonist activity for NMDA recepto......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (5)
Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (4)
SARS-CoV-2, the agent that causes COVID-19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensi......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (9)
KRAS oncoprotein is commonly mutated in human cancer, but effective therapies specifically targeting KRAS-driven tumors remain elusive. Here, we show ......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (6)
Immune checkpoint therapy, where CD8 tumor infiltrating T lymphocytes (TIL) are reactivated, is a promising anti-cancer treatment approach, yet with l......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (8)
On 7 June(,) the FDA approved aducanumab, the first new drug for Alzheimer's disease in almost 20 years-and notably, the first drug with a putative di......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (3)
Growing evidence supports that LKB1-deficient KRAS-driven lung tumors represent a unique therapeutic challenge, displaying strong cancer plasticity th......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (7)
Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human in......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (3)
Herein, we demonstrate that NFAT, a key regulator of the immune response, translocates from cytoplasm to nucleolus and interacts with NF45/NF90 comple......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (5)
Pancreatic beta cells undergo compensatory proliferation in the early phase of type 2 diabetes. While pathways such as FoxM1 are involved in regulatin......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (5)
T cell stimulatory and inhibitory molecules are critical for the regulation of immune responses. In this study, we identify a novel T cell co-inhibito......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (9)
The genus Flavivirus comprises numerous emerging and re-emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivir......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (9)
Bispecific antibodies (bsAb) that target two independent epitopes or antigens have been extensively explored in translational and clinical studies sin......
期刊： EMBO MOLECULAR MEDICINE, 2021; 13 (8)
In the gut, cathelicidin-related antimicrobial peptide (CRAMP) has been largely described for its anti-infective activities. With an increasing recogn......
