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Prediction of Free Drug Absorption in Cyclodextrin Formulation by a Modified Physiologically Based Pharmacokinetic Model and Phase Solubility 3-D Surface Graph

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (7)

Purpose Cyclodextrin (CD) is commonly used to enhance the solubility of oral drugs. However, with the increase of CD concentrations, the fraction of f......

Size-Dependent Absorption through Stratum Corneum by Drug-Loaded Liposomes

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (8)

Purpose Topical treatment of various skin disorders requires drug absorption and penetration through the stratum corneum (SC) into the epidermis and d......

A Photopolymerized Semi-Interpenetrating Polymer Networks-Based Hydrogel Incorporated with Nanoparticle for Local Chemotherapy of Tumors

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (4)

Purpose To address the issue of local drug delivery in tumor treatment, a novel nanoparticle-hydrogel superstructure, namely semi-interpenetrating pol......

Taste Masking Study Based on an Electronic Tongue: the Formulation Design of 3D Printed Levetiracetam Instant-Dissolving Tablets

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (5)

Purpose Proper taste-masking formulation design is a critical issue for instant-dissolving tablets (IDTs). The purpose of this study is to use the ele......

Secondary Packages cannot Protect Liquid Biopharmaceutical Formulations from Dropping-Induced Degradation

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (8)

Purposes Liquid protein-based biopharmaceutical formulations have been reported to form aggregation and protein sub-visible particles (SbVPs) during d......

Strategies for Browning Agent Delivery

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (8)

Y Obesity expands as a global climbing epidemic that is often correlated to cardiovascular diseases and endocrine disorders. Converting white adipocyt......

Molecular, Solid-State and Surface Structures of the Conformational Polymorphic Forms of Ritonavir in Relation to their Physicochemical Properties

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (6)

Purpose Application of multi-scale modelling workflows to characterise polymorphism in ritonavir with regard to its stability, bioavailability and pro......

Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (5)

Purpose The involvement of the intestinally expressed xenobiotic transporters P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) have b......

Preferential Oxycodone Loss of Physically Manipulated Abuse Deterrent Oxycodone HCl Extended Release Tablets Prepared for Nasal Insufflation Studies

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (7)

A method to reproducibly mill abuse deterrent oxycodone hydrochloride (HCl) extended release (ER) tablets was developed for a nasal insufflation pharm......

Application of Affinity-Capture Self-Interaction Nanoparticle Spectroscopy in Predicting Protein Stability, Especially for Co-Formulated Antibodies

期刊: PHARMACEUTICAL RESEARCH, ; ()

Purpose From traditional monoclonal antibodies to more and more complex mAb-based formulations, biopharmaceutical faces one challenge after another. T......

Research on Preparation of 5-ASA Colon-Specific Hydrogel Delivery System without Crosslinking Agent by Mechanochemical Method

期刊: PHARMACEUTICAL RESEARCH, ; ()

Purpose This study aims to overcome the challenges of the current oral targeted drug delivery system, such as the complex preparation process, poor bi......

Optimization of Micafungin Dosage for Chinese Patients with Sepsis in the Intensive Care Unit Based on a Population Pharmacokinetic-Pharmacodynamic Analysis

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (1)

Purpose This study aimed to identify parameters that influence micafungin pharmacokinetics in Chinese patients with sepsis in the intensive care unit ......

Preparation and Evaluation of a Xanthan Gum-Containing Linezolid Ophthalmic Solution for Topical Treatment of Experimental Bacterial Keratitis

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (2)

Purpose To formulate a xanthan gum-containing linezolid ophthalmic solution (LZD-XG) as a new antibiotic treatment against ocular bacterial infection.......

Effects of Different Component Contents of Colistin Methanesulfonate on the Pharmacokinetics of Prodrug and Formed Colistin in Human

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (1)

Purposes To evaluate the effects of component contents in different colistin methanesulfonate (CMS) formulas on their clinical pharmacokinetics of the......

Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation

期刊: PHARMACEUTICAL RESEARCH, 2021; 38 (1)

Purpose Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recent......

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