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20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2021; 154 ()

We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic response and autoregulation of cerebral blood flow (CBF) in rats. The......

Pathophysiological role of prostaglandin E synthases in liver diseases

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2021; 154 ()

Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H-2 (PGH(2)) into prostaglandin E-2 (PGE(2)) and comprise at leas......

20-HETE downregulates Na/K-ATPase alpha 1 expression via the ubiquitination pathway

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2021; 152 ()

In this article, we found that 20-Hydroxyeicosatetraenoic acid (20-HETE) reduced Na/K-ATPase alpha 1 expression via the ubiquitin-proteasome pathway. ......

Lipoxin A4 inhibits the development of endometriosis in a mouse model by suppressing local estradiol synthesis

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2021; 153 ()

We investigated whether lipoxin A4 (LXA4) inhibits the development of endometriosis by suppressing local estradiol synthesis. An endometriosis mouse m......

Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2021; 153 ()

Prostate cancer (PCa) is one of the most fatal malignant tumors that occurs in the prostate epithelium, especially in older men, the mortality of whic......

Seasonal expressions of prostaglandin E synthases and receptors in the prostate of the wild ground squirrel (Spermophilus dauricus)

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 148 ()

The prostate gland is a male accessory reproductive gland, whose vitality and function are under tight regulation of different hormones. Prostaglandin......

Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 149 ()

The accumulation of lipid droplets (LDs) in the cytoplasm plays an important role in energy balance, membrane synthesis and cell signal transduction. ......

The impact of Dl-3-n-butylphthalide on the lipidomics of the hippocampus in a rat model of lipopolysaccharide-induced depression

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 150 ()

Elevated inflammation is commonly observed in depression, but whether this association is causal is not determined. Our previous basic research indica......

Lipoxin A(4) inhibited the activation of hepatic stellate cells-T6 cells by modulating profibrotic cytokines and NF-kappa B signaling pathway

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 146 ()

Background: The deposition of extracellular matrix (ECM) during hepatic fibrosis is an intermediate process in the progression of multiple chronic liv......

Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 146 ()

Background: Acute kidney injury (AKI) is an important complication after major surgery and solid organ transplantation. Here, we present a dietary ome......

Rubusoside-assisted solubilization of poorly soluble C-6-Ceramide for a pilot pharmacokinetic study

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2020; 146 ()

Although C-6-Ceramide has attracted much attention as a possible tumor suppressor, the delivery of C-6-Ceramide is still challenging due to its inhere......

Inhibition of ASM activity ameliorates DSS-induced colitis in mice

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019; 140 ()

Acid sphingomyelinase (ASM) is a membrane lipid hydrolase, acting to generate ceramide and regulate cell functions and inflammatory responses.The role......

JIF:2.25

BML-111, a lipoxin receptor agonist, protects against acute injury via regulating the renin angiotensin-aldosterone system

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019; 140 ()

Background: The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-1......

JIF:2.25

Detoxification and activating blood circulation decoction reduces restenosis involving the TLR4/NF-kappa B pathway after balloon injury

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019; 140 ()

Restenosis is a major problem after percutaneous coronary intervention (PCI) treatment. Inflammation is one of the major core mechanisms involved in t......

JIF:2.25

Regulation of nicotinic acetylcholine receptor alpha 3 subtype in adipose tissue dysfunction

期刊: PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2019; 142 ()

Nicotinic acetylcholine receptor alpha 3 subtype (alpha 3-nAChR) plays a pivotal role in regulating inflammatory responses. Inflammation leads to the ......

JIF:2.25

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