期刊: MOLECULAR PAIN, 2021; 17 ()
FXYD6, an unnecessary auxiliary subunit of Na+,K+-ATPase, is expressed in the nervous system. However, its functions remain largely unclear. In the pr......
期刊: MOLECULAR PAIN, 2021; 17 ()
Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease. Chronic pain is experienced by the vast majority o......
期刊: MOLECULAR PAIN, 2021; 17 ()
Cancer-associated pain is debilitating. However, the mechanism underlying cancer-induced spontaneous pain and evoked pain remains unclear. Here, using......
期刊: MOLECULAR PAIN, 2021; 17 ()
Background Spinal GABAergic neurons act as a critical modulator in sensory transmission like pain or itch. The monosynaptic or polysynaptic primary af......
期刊: MOLECULAR PAIN, 2021; 17 ()
Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active in......
期刊: MOLECULAR PAIN, 2021; 17 ()
Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process of microglia polari......
期刊: MOLECULAR PAIN, 2021; 17 ()
Neuropathic pain is a severe problem that is difficult to treat clinically. Reducing abnormal remodeling of dendritic spines/synapses and increasing t......
期刊: MOLECULAR PAIN, 2021; 17 ()
Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly occurring in the elderly patients. Berberine (BBR) is an isoquino......
期刊: MOLECULAR PAIN, 2021; 17 ()
Pain is a serious clinical challenge, and is associated with a significant reduction in quality of life and high financial costs for affected patients......
期刊: MOLECULAR PAIN, 2020; 16 ()
Low back pain is a chronic, highly prevalent, and hard-to-treat condition in the elderly. Clinical studies indicate that AXL, which belongs to the tyr......
期刊: MOLECULAR PAIN, 2020; 16 ()
Background Chronic pain is frequently comorbid with anxiety disorder, thereby complicating its treatment. Polydatin, a component from the root of Poly......
期刊: MOLECULAR PAIN, 2020; 16 ()
Management of chronic pain is still hard, and new analgesic drugs are needed. Evodiamine (Evo) and rutaecarpine (Rut) are two major active components ......
期刊: MOLECULAR PAIN, 2020; 16 ()
Knee osteoarthritis (OA) pain is the most common joint pain. Currently, dysfunction in the central nervous system rather than knee joint degeneration ......
期刊: MOLECULAR PAIN, 2020; 16 ()
This cross-sectional study investigated whether the catechol-O-methyltransferase (COMT) gene acts as a significant regulator of pain signaling pathway......
期刊: MOLECULAR PAIN, 2020; 16 ()
Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. ......