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FXYD6 promotes thermal nociception by regulating TRPV1

期刊: MOLECULAR PAIN, 2021; 17 ()

FXYD6, an unnecessary auxiliary subunit of Na+,K+-ATPase, is expressed in the nervous system. However, its functions remain largely unclear. In the pr......

Cellular and synaptic mechanisms for Parkinson's disease-related chronic pain

期刊: MOLECULAR PAIN, 2021; 17 ()

Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease. Chronic pain is experienced by the vast majority o......

Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats

期刊: MOLECULAR PAIN, 2021; 17 ()

Cancer-associated pain is debilitating. However, the mechanism underlying cancer-induced spontaneous pain and evoked pain remains unclear. Here, using......

Spinal GABAergic neurons are under feed-forward inhibitory control driven by A delta and C fibers in Gad2 td-Tomato mice

期刊: MOLECULAR PAIN, 2021; 17 ()

Background Spinal GABAergic neurons act as a critical modulator in sensory transmission like pain or itch. The monosynaptic or polysynaptic primary af......

Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund's adjuvant-induced mouse model

期刊: MOLECULAR PAIN, 2021; 17 ()

Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active in......

Short-chain fatty acids contribute to neuropathic pain via regulating microglia activation and polarization

期刊: MOLECULAR PAIN, 2021; 17 ()

Microglia activation and subsequent pro-inflammatory responses play a key role in the development of neuropathic pain. The process of microglia polari......

Electroacupuncture may alleviate neuropathic pain via suppressing P2X7R expression

期刊: MOLECULAR PAIN, 2021; 17 ()

Neuropathic pain is a severe problem that is difficult to treat clinically. Reducing abnormal remodeling of dendritic spines/synapses and increasing t......

Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic encephalopathy

期刊: MOLECULAR PAIN, 2021; 17 ()

Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly occurring in the elderly patients. Berberine (BBR) is an isoquino......

The emerging role of kainate receptor functional dysregulation in pain

期刊: MOLECULAR PAIN, 2021; 17 ()

Pain is a serious clinical challenge, and is associated with a significant reduction in quality of life and high financial costs for affected patients......

AXL signaling in primary sensory neurons contributes to chronic compression of dorsal root ganglion-induced neuropathic pain in rats

期刊: MOLECULAR PAIN, 2020; 16 ()

Low back pain is a chronic, highly prevalent, and hard-to-treat condition in the elderly. Clinical studies indicate that AXL, which belongs to the tyr......

Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model

期刊: MOLECULAR PAIN, 2020; 16 ()

Background Chronic pain is frequently comorbid with anxiety disorder, thereby complicating its treatment. Polydatin, a component from the root of Poly......

Evodiamine reduced peripheral hypersensitivity on the mouse with nerve injury or inflammation

期刊: MOLECULAR PAIN, 2020; 16 ()

Management of chronic pain is still hard, and new analgesic drugs are needed. Evodiamine (Evo) and rutaecarpine (Rut) are two major active components ......

Spinal NF-kB upregulation contributes to hyperalgesia in a rat model of advanced osteoarthritis

期刊: MOLECULAR PAIN, 2020; 16 ()

Knee osteoarthritis (OA) pain is the most common joint pain. Currently, dysfunction in the central nervous system rather than knee joint degeneration ......

COMT gene variants and beta-endorphin levels contribute to ethnic differences in experimental pain sensitivity

期刊: MOLECULAR PAIN, 2020; 16 ()

This cross-sectional study investigated whether the catechol-O-methyltransferase (COMT) gene acts as a significant regulator of pain signaling pathway......

Overexpression of microRNA-185 alleviates intervertebral disc degeneration through inactivation of the Wnt/beta-catenin signaling pathway and downregulation of Galectin-3

期刊: MOLECULAR PAIN, 2020; 16 ()

Background Recent studies have found that microRNAs (miRNAs) play a critical role in development and progression of intervertebral disc degeneration. ......

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