期刊： CLINICAL CHEMISTRY, 2021; 67 (4)
BACKGROUND: Double-stranded DNA in plasma is known to carry single-stranded ends, called jagged ends. Plasma DNA jagged ends are biomarkers for pathop......
期刊： CLINICAL CHEMISTRY, 2021; 67 (5)
BACKGROUND: Although the characterization of cell-free extrachromosomal circular DNA (eccDNA) has gained much research interest, the methylation statu......
期刊： CLINICAL CHEMISTRY, 2021; 67 (8)
Background: Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has emerged as a promising diagnostic technology for bloodstream inf......
期刊： CLINICAL CHEMISTRY, 2021; 67 (4)
BACKGROUND: Antimicrobial resistance (AMR) of Neisseria gonorrhoeae has spread worldwide. Rapid and comprehensive methods are needed to describe N. go......
期刊： CLINICAL CHEMISTRY, 2021; 67 (4)
BACKGROUND: Infectious disease outbreaks such as the COVID-19 (coronavirus disease 2019) pandemic call for rapid response and complete screening of th......
期刊： CLINICAL CHEMISTRY, 2021; 67 (2)
BACKGROUND: Recent studies have reported that examining the fragmentation profiles (FP) of plasma cell-free DNA (cfDNA) further improves the clinical ......
期刊： CLINICAL CHEMISTRY, 2020; 66 (1)
BACKGROUND: Current noninvasive assays for urothelial carcinoma (UC) lack clinical sensitivity and specificity. Given the utility of plasma cell-free ......
期刊： CLINICAL CHEMISTRY, 2020; 66 (1)
BACKGROUND: Targeted next-generation sequencing is a powerful method to comprehensively identify biomarkers for cancer. Starting material is currently......
期刊： CLINICAL CHEMISTRY, 2020; 66 (2)
BACKGROUND: An inversion of intron 22 in the Factor VIII gene (Inv22) is the causative mutation for 45% of severe hemophilia A cases. Available method......
期刊： CLINICAL CHEMISTRY, 2020; 66 (2)
BACKGROUND: Dysregulation of N-6-methyladenosine (m(6)A) is associated with various human diseases including cancer. This study aimed to evaluate the ......
期刊： CLINICAL CHEMISTRY, 2020; 66 (3)
BACKGROUND: Capture sequencing (CS) is widely applied to detect small genetic variations such as single nucleotide variants or indels. Algorithms base......
