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CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

Small cell lung cancer (SCLC) is characterized by a high relapse rate, drug tolerance, and limited treatment choices. Chimeric antigen receptor (CAR)-......

JIF:4.277

Alveolar macrophage-derived NRP2 curtails lung injury while boosting host defense in bacterial pneumonia

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

Clearance of airway intruders by immune cells is required to resolve infectious pneumonia. However, the molecular mechanisms underlying this process r......

JIF:4.277

Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

IL-10-producing regulatory B (Breg) cells are well recognized for maintaining immune tolerance. The impaired Breg cell function with decreased IL-10-p......

JIF:4.277

Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjogren's syndrome by secreting soluble PD-L1

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (5)

Mesenchymal stem cell transplantation (MSCT) regulates immune cells, and is a promising therapeutic approach for treating autoimmune diseases. Stem ce......

JIF:4.277

SUZ12 participates in the proliferation of PNH clones by regulating histone H3K27me3 levels

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (2)

Paroxysmal nocturnal hemoglobinuria (PNH) is a disease involving hematopoietic stem cell membrane defects caused by acquired phosphatidylinositol glyc......

JIF:4.277

Gab2 promotes acute myeloid leukemia growth and migration through the SHP2-Erk-CREB signaling pathway

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

Acute myeloid leukemia (AML) is a hematologic malignant disease largely affecting older adults with poor outcomes. Lack of effective targeted treatmen......

JIF:4.277

Single-cell phenotypic profiling to identify a set of immune cell protein biomarkers for relapsed and refractory diffuse large B cell lymphoma: A single-center study

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (6)

Diffuse large B-cell lymphoma (DLBCL) is the most common invasive type of non-Hodgkin lymphoma. Cell-of-origin (COO) classification is related to pati......

JIF:4.277

LncRNA TUG1 ameliorates diabetic nephropathy via inhibition of PU.1/RTN1 signaling pathway

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (3)

Diabetic nephropathy (DN) is a leading cause of end-stage renal failure. The study aimed to investigate whether long noncoding RNA taurine-upregulated......

JIF:4.277

Hemin-primed dendritic cells suppress allergic airway inflammation through releasing extracellular vesicles

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (4)

Hemin, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles. However,......

JIF:4.277

Hemagglutinin-based DNA vaccines containing trimeric self-assembling nanoparticles confer protection against influenza

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

Influenza viruses continue to threaten public health, and currently available vaccines provide insufficient immunity against seasonal and pandemic inf......

JIF:4.277

K48-and K27-mutant ubiquitin regulates adaptive immune response by affecting cross-presentation in bone marrow precursor cells

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (1)

K48-linked ubiquitination determines antigen degradation and plays vital roles in the process of cross-presentation of bone marrow precursor cell (BMP......

JIF:4.277

IL-17A aggravates asthma-induced intestinal immune injury by promoting neutrophil trafficking

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

With the concept of the gut-lung axis reinforced in recent years, emerging evidence has shown that intestinal homeostasis is vital for lung health. Ne......

JIF:4.277

Anticancer effects of disulfiram in T-cell malignancies through NPL4-mediated ubiquitin-proteasome pathway

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

T-cell malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma (TCL), are characterized by inferior treatment effects,......

JIF:4.277

IL-17A produced by invariant natural killer T cells and CD3(+)CD56(+)alpha Galcer-CD1d tetramer(-) T cells promote liver fibrosis in patients with primary biliary cholangitis

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (5)

Primary biliary cholangitis (PBC) is characterized as interlobular bile duct injury and fibrosis, which results from the loss of tolerance to self-ant......

JIF:4.277

gamma delta T cell exhaustion: Opportunities for intervention

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (6)

T lymphocytes are the key protective contributors in chronic infection and tumor, but experience exhaustion by persistent antigen stimulation. As an u......

JIF:4.277

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