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MicroRNA-363-3p promotes apoptosis in response to cadmium-induced renal injury by down-regulating phosphoinositide 3-kinase expression

期刊: TOXICOLOGY LETTERS, 2021; 345 ()

We previously determined that specific microRNAs (miRNAs) are involved in renal pathophysiological occurrences induced by cadmium (Cd) in rats. This s......

Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats

期刊: TOXICOLOGY LETTERS, 2021; 349 ()

Exposure to sterigmatocystin (STC) raises concerns on developmental neurological disorders. The present study investigated the effects of maternal ora......

Analysis of the microRNA and mRNA expression profile of ricin toxin-treated RAW264.7 cells reveals that miR-155-3p suppresses cell inflammation by targeting GAB2

期刊: TOXICOLOGY LETTERS, 2021; 347 ()

Ricin toxin (RT) is one of the most lethal toxins derived from the seed of castor beans. In addition to its main toxic mechanism of inhibiting the syn......

Maternal smoking during pregnancy aggravated muscle phenotype in FHL1(-/y) offspring mice similar to congenital clubfoot through P2RX7-mediated pyroptosis

期刊: TOXICOLOGY LETTERS, 2021; 345 ()

Congenital clubfoot (CCF) is a common birth defect. Maternal smoking during pregnancy increases the risk of CCF. In previous research, we found muscle......

Acrolein-conjugated proteomics in brains of adult C57BL/6 mice chronically exposed to acrolein and aged APP/PS1 transgenic AD mice

期刊: TOXICOLOGY LETTERS, 2021; 344 ()

Acrolein is a universal contaminant with high nucleophilicity in environment and also an endogenous product from lipid peroxidation or polyamine metab......

Analysis of serum metabolome of workers occupationally exposed to hexavalent chromium: A preliminary study

期刊: TOXICOLOGY LETTERS, 2021; 349 ()

Hexavalent chromium (Cr(VI)) compound is considered as a common environmental and occupational pollutant due to widespread application in industry and......

Exposure to biomass smoke induces pulmonary Th17 cell differentiation by activating TLR2 on dendritic cells in a COPD rat model

期刊: TOXICOLOGY LETTERS, 2021; 348 ()

Almost three billion people in developing countries are exposed to biomass smoke (BS), which predisposes them to developing chronic obstructive pulmon......

LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling

期刊: TOXICOLOGY LETTERS, 2021; 348 ()

Antimony is a common environmental contaminant that causes biological toxicity in exposed populations worldwide. Previous studies have revealed that a......

Bisphenol F promotes the secretion of pro-inflammatory cytokines in macrophages by enhanced glycolysis through PI3K-AKT signaling pathway

期刊: TOXICOLOGY LETTERS, 2021; 350 ()

Bisphenol F (BPF) is a member of endocrine disrupting chemicals (EDCs). As a substitute of bisphenol A (BPA), BPF is widely used in various consumer p......

Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss

期刊: TOXICOLOGY LETTERS, 2021; 350 ()

Cisplatin-induced hearing loss is a common side effect of cisplatin chemotherapy, for which clinical therapy remains unavailable. Apoptosis of hair ce......

Myricetin and M10, a myricetin-3-O-beta-d-lactose sodium salt, modify composition of gut microbiota in mice with ulcerative colitis

期刊: TOXICOLOGY LETTERS, 2021; 346 ()

Our previous studies found that M10, a myricetin-3-O-beta-d-lactose sodium salt, possessed higher effects of ameliorating ulcerative colitis (UC) than......

Inhibition of desmoglein-1 by aspirin leads to synthetic lethality of keratinocytes in Shuanghuanglian-induced cutaneous eruption response

期刊: TOXICOLOGY LETTERS, 2021; 349 ()

Cutaneous eruptions caused by the combination of Chinese and Western medicine have attracted widespread attention; however, the underlying mechanism r......

The Circ_CARM1 controls cell migration by regulating CTNNBIP1 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells

期刊: TOXICOLOGY LETTERS, 2021; 348 ()

Background: Circular RNAs (circRNAs) have an important role in the development and progression of human tumors, including lung cancer. Yet, their role......

Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model

期刊: TOXICOLOGY LETTERS, 2021; 349 ()

Pesticides exposure can lead to damage of dopaminergic neurons, which are associated with increased risk of Parkinson's disease (PD). However, the eti......

CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis

期刊: TOXICOLOGY LETTERS, 2021; 347 ()

For smoking-induced pulmonary fibrosis (PF), a serious disease endangering human health, there is no effective clinical treatment. Aberrant epithelium......

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