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Studies on the compatibility mechanism and material basis of Danggui Buxue Decoction against anemia mice using metabonomics and network pharmacology

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (6)

Objectives To reveal the compatibility mechanism and material basis of Danggui Buxue decoction (DBD) against anaemia. Methods UHPLC-Q-Exactive-MS base......

1,8-cineole ameliorates ischaemic brain damage via TRPC6/CREB pathways in rats

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (7)

Objectives A previous in vitro study reported that the monoterpene oxide 1,8-cineole (cineole) attenuates neuronal caused by oxygen-glucose deprivatio......

Hypericin-mediated photodynamic therapy for the treatment of cancer: a review

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (4)

Objectives Hypericin is a polycyclic aromatic naphthodianthrone that occurs naturally. It is also an active ingredient in some species of the genus Hy......

Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NF kappa B signalling pathway

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (6)

Objectives Clinical endometritis is a common reproductive disorder in mammals that seriously endangers animal health and causes economic losses worldw......

Sorafenib suppresses proliferation rate of fibroblast-like synoviocytes through the arrest of cell cycle in experimental adjuvant arthritis

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (1)

Objectives Rheumatoid arthritis, a recurrent incendiary autoimmune joint syndrome, features by prominent synovial hyperplasia. Fibroblast-like synovio......

Propofol suppresses osteosarcoma cell function by regulating FOXO1/TUSC7

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (6)

Objectives Accumulated evidence demonstrates that propofol has antitumour roles in various cancers. However, the role of propofol in osteosarcoma is s......

Medicinal plants from the Himalayan region for potential novel antimicrobial and anti-inflammatory skin treatments

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (7)

Background and Objectives Adequate treatment of wounds remains one of the major medical needs globally, most notably in the regions with poor or limit......

Xanthohumol ameliorates memory impairment and reduces the deposition of beta-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (9)

Objectives Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. In this study, we investi......

Osthole improves pulmonary artery hypertension by inducing apoptosis in pulmonary artery smooth muscle cells

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (8)

Objectives The objectives of this study were to explore the effect of Osthole (Ost) on apoptosis in pulmonary artery smooth muscle cells (PASMCs) and ......

Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (8)

Objectives In this study, we sought to evaluate purpurin, a natural biomedicine and a potential inhibitor in decreasing the growth rate of lung cancer......

Sildenafil improves right ventricular remodelling in monocrotaline-induced rats by decreasing myocardial apoptosis and activating peroxisome proliferator-activated receptors

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (2)

Objectives To assess the effect of sildenafil on monocrotaline-induced right ventricular (RV) remodeling and investigate the possible mechanism. Metho......

Paeoniflorin modulates oxidative stress, inflammation and hepatic stellate cells activation to alleviate CCl4-induced hepatic fibrosis by upregulation of heme oxygenase-1 in mice

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (3)

Objectives The role of Paeoniflorin on hepatic fibrosis and the specific mechanisms has not yet been elucidated. Therefore, we explored whether Paeoni......

NUPR1 participates in YAP-mediate gastric cancer malignancy and drug resistance via AKT and p21 activation

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (6)

Objectives To assess nuclear protein 1 (NUPR1) level in human gastric cancer (GC) cells, explore the effects of NUPR1 on GC progression, and investiga......

Essential role of protein kinase C beta I in icariin-mediated protection against atherosclerosis

期刊: JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021; 73 (9)

Objectives This study aimed to clarify the superior beneficial effects of icariin on atherosclerosis, as well as to explore the possible underlying me......

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