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Etoricoxib may inhibit cytokine storm to treat COVID-19

期刊: MEDICAL HYPOTHESES, 2021; 150 ()

The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19mediated cytokine storm is one of the most important c......

PIEZO1 might be involved in cerebral ischemia-reperfusion injury through ferroptosis regulation: a hypothesis

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

Stroke is associated with high mortality and extremely high disability rate. Regulating ferroptosis seems to be a promising way to treat ischemic stro......

Pyroptotic cell-derived microparticle: An atherogenic factor in infectious diseases

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

Chronic infection is considered a risk factor for atherosclerosis. The link between infectious agents and atherosclerosis is manifested by the presenc......

The potential mechanisms of piRNA to induce hepatocellular carcinoma in human

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

The hepatocellular carcinoma, as one of the most frequently happened types of cancer in the world, has very complicated intracellular and extracellula......

B cell receptor (BCR) guided mechanotransduction: Critical hypothesis to instruct SARS-CoV-2 specific B cells to trigger proximal signalling and antibody reshaping

期刊: MEDICAL HYPOTHESES, 2021; 153 ()

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has spread around the globe with remarkable consequences for the ......

The hypothetical molecular pathways of ursolic acid to attenuate the premature ovarian failure in human

期刊: MEDICAL HYPOTHESES, 2021; 153 ()

Premature ovarian failure, which is also called premature menopause, refers to the stop of menstruation and the formation of oocyte before 40 years ol......

The kappa opioid receptor may be a potential tumor suppressor by regulating angiogenesis in breast cancer

期刊: MEDICAL HYPOTHESES, 2021; 150 ()

Our hypothesis proposes that activating x-opioid receptors (KORs) may inhibit the progression of breast cancer and improve patient prognosis. Conseque......

Remote ischemic conditioning: A potential therapeutic strategy of type 2 diabetes

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

Type 2 diabetes (T2D) is one of the major public diseases which is characterized by peripheral insulin resistance (IR) and progressive pancreatic I3-c......

Targeting mitochondrial dysfunction in MAIT cells: Potential immunotherapeutic treatment for colorectal cancer

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

Mucosal associated invariant T (MAIT) cells have captured the attention of immunologists and clinicians in recent years due to their abundance in huma......

Nerve plane: An optimal surgical plane for laparoscopic rectal cancer surgery?

期刊: MEDICAL HYPOTHESES, 2021; 154 ()

Radical resection for rectal cancer with total mesorectal excision has been widely recognized in mid-low rectal cancer. Although such surgery reduced ......

COVID-19 changes the lifestyle of the population and subtly reduces the incidence of metabolic disease

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

The COVID-19 pandemic has placed significant restrictions on people's daily activities and even change their eating habits, yet it has inadvertently a......

Peptidyl arginine deiminase 4 and its potential role in Alzheimer's disease

期刊: MEDICAL HYPOTHESES, 2021; 146 ()

Alzheimer's disease (AD) is the main cause of dementia, and its pathogenesis is still not clear. Peptidyl arginine deiminases 4(PAD4) as one of the im......

The uncoupled anterior and posterior spinal ligament tension (UAPLT)-An improvement to three-dimensional spring model of adolescent idiopathic scoliosis (AIS) pathogenesis

期刊: MEDICAL HYPOTHESES, 2021; 152 ()

The pathogenesis of Adolescent Idiopathic Scoliosis (AIS) remains unclear. Previous research proposed that ligament laxity is a clinical feature that ......

Stromal cell-derived factor-1 may play pivotal role in distraction-stimulated neovascularization of diabetic foot ulcer

期刊: MEDICAL HYPOTHESES, 2021; 149 ()

Diabetic foot ulcer (DFU) has become a major medical, social and economic concern worldwide. It is highly desirable to develop promising new solutions......

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