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Puerarin-Na Chelate Hydrate Simultaneously Improves Dissolution and Mechanical Behavior

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Puerarin monohydrate (PUEM), as the commercial solid form of the natural anti-hypertension drug puerarin (PUE), has low solubility, poor flowability, ......

Nanodelivery Systems for Topical Management of Skin Disorders

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (2)

Topical drug delivery has inherent advantages over other administration routes. However, the existence of stratum corneum limits the diffusion to smal......

Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (4)

Berberine (BBR) is currently explored in the oral treatment of many disorders, especially in those involving inflammatory processes. Nanotechnology-ba......

Effect of Protein Corona on Mitochondrial Targeting Ability and Cytotoxicity of Triphenylphosphonium Conjugated with Polyglycerol-Functionalized Nanodiamond

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Functionalization of nanoparticles (NPs) with targeting moieties has a high potential to advance precision nanomedicine. However, the targeting moieti......

Influence of Adsorption State and Molecular Interaction on Physical Stability of Confined Amorphous Vortioxetine

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

The composites of amorphous vortioxetine (VXT) and ordered mesoporous silica were prepared. Three silica matrixes with different pore sizes were used ......

Morphology/Interstitial Fluid Pressure-Tunable Nanopomegranate Designed by Alteration of Membrane Fluidity under Tumor Enzyme and PEGylation

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (5)

Up to now, insufficient drug accumulation in tumor remains a major challenge for nanochemotherapy. However, the spherical nanocarriers with large diam......

Combining Mechanical High-Intensity Focused Ultrasound Ablation with Chemotherapy for Augmentation of Anticancer Immune Responses

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (5)

As a noninvasive therapy, high-intensity focused ultrasound (HIFU) shows great potential in inducing anticancer immune responses. However, the overall......

Inhalable Porous Microspheres Loaded with Metformin and Docosahexaenoic Acid Suppress Tumor Metastasis by Modulating Premetastatic Niche

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Cancer metastasis is the major cause of cancer-related death; therefore, achieving suppression of tumor metastasis is a long-sought goal in cancer the......

mPEG(2k)-PCLx Polymeric Micelles Influence Pharmacokinetics and Hypoglycemic Efficacy of Metformin through Inhibition of Organic Cation Transporters in Rats

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Increasing evidence has shown that nanocarriers have effects on several efflux drug transporters. To date, little is known about whether influx transp......

miR-194-Loaded Gelatin Nanospheres Target MEF2C to Suppress Muscle Atrophy in a Mechanical Unloading Model

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (8)

Muscle atrophy usually occurs under mechanical unloading, which increases the risk of injury to reduce the functionality of the moving system, while t......

Combining Gemcitabine-Loaded Macrophage-like Nanoparticles and Erlotinib for Pancreatic Cancer Therapy

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Pancreatic cancer is a lethal malignancy with a dismal prognosis. Gemcitabine is currently used to treat pancreatic cancer, but it is limited by signi......

Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (5)

Intestinal efflux transporters affect the gastrointestinal processing of many drugs but further data on their intestinal expression levels are require......

Understanding the Synergistic Correlation between the Spatial Distribution of Drug-Loaded Mixed Micellar Systems and In Vitro Behavior via Experimental and Computational Approaches

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (4)

To better promote the application of polymeric mixed micelles (PMMs), a coarse-grained molecular dynamics simulation (CGMD) has been employed to inves......

Administration Routes of Polyethylenimine-Coated PLGA Nanoparticles Encapsulating Angelica Sinensis Polysaccharide Vaccine Delivery System Affect Immune Responses

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (6)

Nanoparticle vaccine delivery systems have been emerging strategies for inducing potent immune responses to prevent and treat infectious diseases and ......

Integrin alpha(2)beta(1) Targeting DGEA-Modified Liposomal Doxorubicin Enhances Antitumor Efficacy against Breast Cancer

期刊: MOLECULAR PHARMACEUTICS, 2021; 18 (7)

Breast cancer was the leading cause of newly diagnosed cases of tumors in 2020, ranking as the second highest cause of female death. Chemotherapy rema......

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