Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade-MedSci.cn

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Okada, R; Zhang, XW; Harada, Y; Wu, Z; Nakanishi, H

Nakanishi, H (reprint author), Kyushu Univ, Fac Dent Sci, Dept Aging Sci & Pharmacol, Fukuoka 8128582, Japan.; Nakanishi, H (reprint author), Yasuda Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Hiroshima 7310153, Japan.

Abstract

The objective of this study is to investigate the role of cathepsin H (CatH), a lysosomal cysteine protease, in the development of experimental autoim......

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Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

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