An UPLC-MS/MS method for the determination of EAI045 in plasma and tissues and its application to pharmacokinetic and distribution studies in rats

Lv, HD; Shen, EZ; Luo, L; Xu, Y; Pan, YQ; Wu, KQ; Xing, ZC; Ye, FQ; Zhang, Y

Ye, FQ; Zhang, Y (reprint author), Wenzhou Med Univ, Wenzhou 325035, Peoples R China.

PHARMAZIE, 2018; 73 (11): 630

Abstract

EAI045 represents a fourth generation allosteric EGFR TKI compound which targets T790M and C797S EGFR mutants. The study reported herein describes a m......

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