Targeting IFN alpha to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance

Liang, Y; Tang, HD; Guo, JY; Qiu, XY; Yang, ZC; Ren, ZH; Sun, ZC; Bian, YJ; Xu, LL; Xu, HR; Shen, J; Han, YF; Dong, HD; Peng, H; Fu, YX

Peng, H (reprint author), Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China.; Tang, HD (reprint author), Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China.; Tang, HD; Fu, YX (reprint author), Univ Tex

NATURE COMMUNICATIONS, 2018; 9 ():

Abstract

Many patients remain unresponsive to intensive PD-1/PD-L1 blockade therapy despite the presence of tumor-infiltrating lymphocytes. We propose that imp......

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