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JOURNAL OF CARDIAC FAILURE, 2011; 17 (12): 1028

Myocardial Deformation Analysis in Chagas Heart Disease With the Use of Speckle Tracking Echocardiography

Garcia-Alvarez, A; Sitges, M; Regueiro, A; Poyatos, S; Pinazo, MJ; Posada, E; Bijnens, B; Heras, M; Gascon, J; Sanz, G
Sanz, G (reprint author), Fdn Ctr Nacl Invest Cardiovasc Carlos III, Melchor Fernandez Almagro 3, Madrid 28029, Spain
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Abstract
Background: Assessment of myocardial deformation in Chagas disease may help us to better understand the disease pathophysiology and to detect early myocardial involvement. We aimed to characterize myocardial deformation in patients in different forms of Chagas disease and, specifically, assess differences between patients in the indeterminate form and controls. Methods and Results: Speckle tracking echocardiography was performed in 98 subjects (22 with Chagas cardiomyopathy, 32 in the indeterminate form, and 44 control subjects) to quantify global and segmental left ventricular (LV) radial strain (RS), circumferential strain (CS), and longitudinal strain (LS). In a subset of patients from the indeterminate and control groups (n = 25), LV peak systolic twist and untwisting velocities were additionally assessed. Global RS, CS, and LS showed a significant decreasing trend across groups. Patients in the indeterminate form had significantly lower global RS and RS in the midinferior segment (median 39.8% vs 49.3% [P = .046] and 44.0% vs 56.0% [P = .038], respectively) and lower twist and untwisting velocity (P < .05 for both) compared with control subjects. Conclusion: Evaluation of myocardial deformation, particularly of RS, appears to be a sensitive technique for detection of myocardial involvement in patients in the indeterminate form and provides insights into the still unrevealed pathophysiology of Chagas heart involvement. (J Cardiac Fail 2011;17: 1028-1034)


JOURNAL OF CARDIAC FAILURE 影响因子:3.32    (投稿经验 | MedSci指数 | 杂志信息 )
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原文查看:Myocardial Deformation Analysis in Chagas Heart Disease With the Use of Speckle Tracking Echocardiography



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