Brit J Cancer:积极监控局部前列腺癌患者的饮食质量和格林森等级恶化研究

2019-02-11 AlexYang MedSci原创

高质量的饮食能够维持较好的代谢和抗炎症状态并且不利于肿瘤的恶化。最近,有研究人员在积极监督局部前列腺癌患者中前瞻性的调查了饮食质量与格林森等级恶化之间的关系;积极监督是一种疾病控制和推迟干预的临床治疗策略。研究包括了新诊断格林森得分在6或者7的前列腺癌男性;这些患者在基线时间点(n=411)和跟踪调查的首6个月(n=263)完成了一份食物频率调查问卷(FFQ)。研究人员还利用Cox比例风险模型来评

高质量的饮食能够维持较好的代谢和抗炎症状态并且不利于肿瘤的恶化。最近,有研究人员在积极监控局部前列腺癌患者中前瞻性的调查了饮食质量与格林森等级恶化之间的关系;积极监控是一种疾病控制和推迟干预的临床治疗策略。

研究包括了新诊断格林森得分在6或者7的前列腺癌男性;这些患者在基线时间点(n=411)和跟踪调查的首6个月(n=263)完成了一份食物频率调查问卷(FFQ)。研究人员还利用Cox比例风险模型来评估调整多变量后饮食质量与格林森等级恶化之间的相关性。研究发现,在平均跟踪调查36个月后,76名男性的病情有恶化。在调整了临床病理因素后,研究人员观察到了基线饮食质量与格林森等级恶化之间存在负相关关系(最高 vs.最低HEI-2015四分位:HR和95%CI分别为0.59 (0.32-1.08); Ptrend=0.06)。研究人员在跟踪调查第6个月时没有观察到与饮食质量的相关性,也没有观察到基线点饮食质量的变化。

最后,研究人员指出,在积极监控局部前列腺癌患者中,更高的饮食质量或者符合美国饮食指南的饮食能够降低格林森等级恶化的风险,但仍旧需要进一步的研究。

原始出处:

Justin R. Gregg, Jiali Zheng, David S. Lopez et al. Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance. Brit J Cancer. 25 Jan 2019.

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    2019-02-13 chg122
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    2019-02-11 1ddf0692m34(暂无匿称)

    学习了,长知识

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