诺奖风向标拉斯克奖花落免疫细胞、赫赛汀发现者和疫苗联盟

2019-09-10 贺梨萍 澎湃新闻

当地时间9月10日,位于美国纽约的阿尔伯特与玛丽拉斯克基金会(Albert and Mary Lasker Foundation)公布了2019年拉斯克医学奖的得主名单。埃默里大学的Max D. Cooper、澳大利亚沃尔特和伊丽莎?霍尔医学研究所(the Walter and Eliza Hall Institute of Medical Research)的Jacques Miller、美国基

当地时间9月10日,位于美国纽约的阿尔伯特与玛丽拉斯克基金会(Albert and Mary Lasker Foundation)公布了2019年拉斯克医学奖的得主名单。埃默里大学的Max D. Cooper、澳大利亚沃尔特和伊丽莎?霍尔医学研究所(the Walter and Eliza Hall Institute of Medical Research)的Jacques Miller、美国基因泰克公司的前科学家H. Michael Shepard、加州大学洛杉矶分校的Dennis J. Slamon、德国马克斯?普朗克生物化学研究所(the Max Planck Institute of Biochemistry)的Axel Ullrich,以及国际组织全球疫苗免疫联盟Gavi分享了2019年拉斯克奖的三个重要奖项。

拉斯克奖在生命科学、医学领域享有盛誉,素有“诺贝尔奖风向标”之称。该奖项于1946年由美国广告经理人、慈善家阿尔伯特?拉斯克(Albert Lasker)及其夫人玛丽?沃德?拉斯克(Mary Woodard Lasker)共同创立,表彰在生命科学、医学领域作出突出贡献的科学家、医生和公共服务人员。此前共设置有三个奖项:基础医学研究奖、临床医学研究奖和公共服务奖,后又增设特殊贡献奖。

迄今为止,在该奖项的所有获得者中,有87人同时获得了诺贝尔奖。其中中国科学家屠呦呦因发现青蒿素于2011年获得“拉斯克临床医学研究奖”,并在2016年成为诺贝尔生理或医学奖得主。

拉斯克奖由阿尔伯特与玛丽拉斯克基金会颁发,三个奖项分别设立25万美元奖金。

基础医学研究奖:B和T细胞的发现

2019年阿尔伯特.拉斯克基础医学研究奖授予两名科学家:Max D. Cooper和Jacques Miller,表彰他们在现代免疫学领域的突出贡献。Max D. Cooper和Jacques Miller两名科学家确定了两种不同类型的淋巴细胞,即B细胞和T细胞。这项开创性的工作推动了基础科学和医学科学的巨大进步,其中一些成就已获得往年拉斯克奖和诺贝尔奖的高度认可,包括与单克隆抗体相关研究、抗体多样性的产生、免疫防御的MHC限制、树突状细胞抗原提呈和癌症检查点抑制疗法等。

临床医学研究奖:针对乳腺癌的靶向抗体疗法

2019年Lasker~DeBakey临床医学研究奖授予三名科学家:H.Michael Shepard,Dennis J. Slamon和Axel Ullrich。他们发明了赫赛汀(Herceptin),这是第一种能够阻断致癌蛋白的单克隆抗体,并将其开发成一种挽救女性乳腺癌患者生命的疗法。这一疗法降低了复发风险,延长了转移性和早期疾病患者的生存时间。

自该药于1999年被美国FDA批准上市,主要用来治疗HER2(人类表皮生长因子受体2)阳性的乳腺癌患者。每年有超过5万名女性被诊断出患有该类型的乳腺癌,自赫赛汀问世以来,已有超过230万人接受了这种治疗。

Shepard和Ullrich曾就职于基因泰克公司,进行赫赛汀研究;Slamon则在加州大学洛杉矶分校进行他的研究。20世纪70年代中期,科学家发现人体自身的基因会引发癌症。这一发现激发了这样一种观点,即扼杀这些癌基因的活性可能会取得治疗效果。这种治疗策略针对性更强,同时可以避免许多与化疗相关的严重副作用。

公共服务奖:国际组织全球疫苗免疫联盟Gavi

2019年拉斯克-布伦伯格公共服务奖授予国际组织全球疫苗免疫联盟Gavi,表彰Gavi在全球范围内持续提供儿童疫苗,从而拯救了数百万人的生命,并突出了免疫预防疾病的力量。

通过利用最新的科学进展、合作和发挥经济影响,Gavi确保以可负担的价格提供充足的疫苗供应,加速新疫苗的开发和部署,并加强医疗保健系统。自2000年创立以来,Gavi已在73个国家帮助超过7.6亿儿童接种疫苗,拯救了1300多万人的生命。

根据世界卫生组织(WHO)的数据,免疫接种每年可使200万-300万人免于死亡。它的成功创造了历史上最引人注目和最具成本效益的公共卫生故事之一。

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    2019-09-12 wrj0122
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    2019-09-12 wumeihua90
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    2019-09-12 zexyw04
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    2019-09-12 txqjm

    谢谢了,学习

    0