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Life Sci Alliance：肠道内稳态和癌发生中的C/EBPα-Wnt连接

2019-01-11 MedSci MedSci原创

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本研究中，我们探讨了C/EBPα（CCAAT /增强子结合蛋白α）与肠道稳态和癌发生过程中Wnt信号的关系。 C/EBPα在隐窝的转运扩增区域中的人和小鼠肠上皮细胞中表达，并且在具有活化的Wnt信号传导的肠干细胞和潘氏细胞中不存在。在人类结肠直肠癌和鼠APCMin/+息肉中，核β-连环蛋白阳性肿瘤细胞中不存在C/EBPα。在化学诱导的肠癌发生中，小鼠肠上皮细胞中的C /EBPαKO增加了肿瘤体积。

本研究中，我们探讨了C/EBPα（CCAAT /增强子结合蛋白α）与肠道稳态和癌发生过程中Wnt信号的关系。

C/EBPα在隐窝的转运扩增区域中的人和小鼠肠上皮细胞中表达，并且在具有活化的Wnt信号传导的肠干细胞和潘氏细胞中不存在。在人类结肠直肠癌和鼠APCMin/+息肉中，核β-连环蛋白阳性肿瘤细胞中不存在C/EBPα。在化学诱导的肠癌发生中，小鼠肠上皮细胞中的C /EBPαKO增加了肿瘤体积。C/EBPα缺失扩展了肠类器官中的S期细胞区并激活了典型的增殖基因表达特征，包括Wnt靶基因的特征。类器官中β-连环蛋白的遗传活化减弱了C/EBPα的表达，并且HCT116细胞中的异位C/EBPα表达消除了细胞增殖。C/EBPα表达伴随结肠癌细胞系Caco-2的分化，而β-连环蛋白稳定化抑制C/EBPα。

综上所述，这些数据表明通过限制Wnt信号传导，肠道中C/EBPα的稳态和致癌抑制功能。

原始出处：

Julian Heuberger, Undine Hill, et al., A C/EBPα–Wnt connection in gut homeostasis and carcinogenesis. Life Sci Alliance. 2019 Feb; 2(1): e201800173.

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    2019-04-21 changfy

    #稳态#

    0

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    2019-08-26 clmlylxy

    #Life#

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    2019-01-12 膀胱癌

    #ALL#

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    2019-01-12 zhwj

    #WNT#

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