Lancet:术前尿DKK3用于心脏手术后急性肾损伤预测

2019-08-12 MedSci MedSci原创

研究发现,术前尿DKK3是术后AKI的独立预测因子

心脏手术与术后急性肾损伤(AKI)及随后肾功能丧失有关。近日研究人员考察了尿Dickkopf-3(DKK 3),一种肾小管应激反应标志物,用于术前AKI及肾功能丧失风险的预测作用。

RenalRIP研究,招募接受心脏手术的患者,评估术前尿DKK 3浓度与肌酐比值(DKK 3/肌酐)与术后AKI的关系。

在包含733名患者的开发队列中,尿中DKK3/肌酐浓度高于471 pg/mg与AKI风险增加显著相关(OR=1.65),该结果独立于基线肾功能。与临床和其他实验室测量结果相比,DKK3/肌酐显著改善了AKI预测。高尿DKK3/肌酐人群在出院时和中位随访820天(IQR733-910)后,肌氨酸酐浓度与肾脏功能显著降低相关。术前尿DKK 3/肌酐浓度高于471 pg/mg与90天后AKI(OR: 1.94)、持续性肾功能不全(OR: 6.67)和透析依赖(OR:13.57)的风险显著高于DKK 3/肌酐浓度为471 pg/mg或更低人群。验证队列中尿DKK 3/肌酐浓度高于471 pg/mg与AKI I(OR 2.79)和持续性肾功能不全(OR 3.82)的风险显著相关。

研究发现,术前尿DKK3是术后AKI的独立预测因子。

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    2020-05-17 howi
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    2019-09-22 liujie6118

    心脏手术与术后急性肾损伤(AKI)及随后肾功能丧失有关!

    0

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