PLos One :CT引导的肺活检后与临床咯血相关的支气管血管损伤

2018-09-24 xiangting MedSci原创

穿刺时可能穿透和割伤1mm或更大的支气管血管结构与PTNB后的临床明显咯血独立相关。

这项研究旨在评估支气管血管损伤是否为经皮经胸腔穿刺活检(PTNB)后临床明显咯血的病因。

研究纳入2014年1月至2017年1月锥束CT(CBCT)引导的PTNB后出现咯血的111名连续性患者。临床明显咯血定义为导致血流动力学不稳定或氧去饱和大于基线10%的咯血。在CT图像上评估病变特征。在CBCT图像上评估沿引导针轨迹和活检枪发射时潜在穿透的支气管血管结构。在活检标本中对支气管血管结构的切割损伤进行组织病理学评估。使用logistic回归分析评估临床明显咯血的相关因素。

17名患者有临床明显咯血(15.3%;95%CI,9.7%-23.2%)。在单因素分析中,支气管开放征(P=.004)、结节硬度(P=.012)、射击时可能穿透1mm或更大的肺血管或支气管(分别为P=.008和P=.038) 、割伤1mm或更大的肺血管(P=.007)或支气管结构(P=.041)与临床明显咯血相关。多因素分析发现了以下显著相关因素:射击时可能穿透1mm或更大的肺血管(OR,3.874; 95%CI,1.072-13.997; P=.039)、割伤1mm或更大的肺血管(OR,6.920; 95%CI,1.728-27.711; P=.006 )或支气管结构(OR 4.604; 95%CI,1.194-17.755; P=.027)。

穿刺时可能穿透和割伤1mm或更大的支气管血管结构与PTNB后的临床明显咯血独立相关。

原始出处

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    2018-09-26 mfx801
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    2018-09-26 feather80

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