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Dent Mater J：FGF羟基磷灰石纳米颗粒粉末作为盖髓材料的应用

2019-07-11 lishiting MedSci原创

FGFHAP
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作者之前构建了羟基磷灰石(HAP)纳米微粒组成的粉末(nano-HAP)并装配了未添加模板/粘接分子或施加高温/压处理的低晶度HAP纳米微粒。

作者之前构建了羟基磷灰石(HAP)纳米微粒组成的粉末(nano-HAP)并装配了未添加模板/粘接分子或施加高温/压处理的低晶度HAP纳米微粒。

在这篇研究中，作者将nano-HAP与能够促进成牙本质细胞分化的FGF2相结合，并将其作为盖髓材料应用于大鼠磨牙的牙本质缺损上。在盖髓后的1和2周，对组织反应进行X线及组织学评估，以检测其生物相容性和这种材料促进硬组织形成的能力。

结果显示，nano-HAP/FGF2可以诱导牙髓细胞和血管的侵入，并持续发现富含大量牙本质小管的牙本质桥形成。可以说，作者采用生理学的方法通过促进组织再生成功的治愈了牙髓暴露。然而，还需要更多的研究来确切的解释nano-HAP/FGF2联合物如何促进钙化组织的形成。

原始出处：

Imura K， Hashimoto Y， et al. Application of hydroxyapatite nanoparticle-assembled powder using basic fibroblast growth factor as a pulp-capping agent. Dent Mater J. 2019 Jun 13. doi： 10.4012/dmj.2018-198.

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    2019-11-23 limedical1974

    #盖髓材料#

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    2019-07-13 ms3117646317107274

    #纳米颗粒#

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    2019-07-13 爆笑小医

    #羟基磷灰石#

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