J Viral Hepat：IFNAR2 -rs1051393, rs12233338可能是中国人群HBV感染的预测标志物

2018-04-16 MedSci MedSci原创

IFNAR2 -rs1051393， rs12233338可能是中国人群HBV感染的预测标志物

研究背景：最近的研究表明，某些干扰素基因和干扰素受体基因的变异与感染性疾病有关。本研究在汉族人群中分析了乙肝病毒(HBV)相关肝脏疾病的风险与IFNL4、IFNLR1、IFNA1、IFNA2、IFNA5和IFNAR2基因(14个基因位点)功能多态性的相关性。

研究方法：本研究纳入3128例参与者，将其分为健康对照组、自然清除组，慢性乙型肝炎(CHB)组，肝硬化（LC）和肝细胞癌组。

研究结果：IFNAR、IFNLR1的4种变异与HBV感染有关，IFNLR1-rs4649203与HBV感染的恢复有关。此外，在IFNA1、IFNA2、IFNL4和HCC中显示了5个多态性的明显相关性。IFNL4基因中的3个SNPs可能是HBV相关肝病进展中是重要的易感因素。由rs12971396_G、rs8113007_T和rs7248668A组成的IFNL4单倍体在HCC中比在CHB和LC组更常见。IFNL4基因5'区的3个多态性与HBV相关肝脏疾病的进展有关。IFNA1- rs1831583和IFNA2- rs649053与HCC的发展有关。IFNLR1- rs4649203， rs7525481是HBV感染的预测因子，rs4649203是自发清除的预测因子。

研究结论：IFNAR2 -rs1051393， rs12233338可能是中国人群HBV感染的预测标志物。

原始出处：

Ma N， Zhang X， Yang L， et al. Role of Functional IFNL4， IFNLR1， IFNA， IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population. J Viral Hepat， 2018， 25(3)， 306-313. doi： 10.1111/jvh.12817.

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2018-07-02 klivis

#HBV#

39 0
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2018-08-27 passed water

#FNA#

40 0
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2018-06-15 hukaixun

#标志物#

28 0
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2018-04-18 gwc384

#EPA#

30 0
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2018-04-18 Tommy1951

#HBV感染#

35 0
[GetPortalCommentsPageByObjectIdResponse(id=1836659, encodeId=982d1836659ba, content=<a href='/topic/show?id=f9d08524be' target=_blank style='color:#2F92EE;'>#HBV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8524, encryptionId=f9d08524be, topicName=HBV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Mon Jul 02 02:00:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2021971, encodeId=1fdf20219e178, content=<a href='/topic/show?id=e9e6e55483' target=_blank style='color:#2F92EE;'>#FNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7554, encryptionId=e9e6e55483, topicName=FNA)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Mon Aug 27 06:00:00 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1841220, encodeId=788f184122091, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 15 01:00:00 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427082, encodeId=a3c2142e08289, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Wed Apr 18 13:00:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462196, encodeId=0f9a1462196e2, content=<a href='/topic/show?id=b97885350d' target=_blank style='color:#2F92EE;'>#HBV感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8535, encryptionId=b97885350d, topicName=HBV感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33ed6479538, createdName=Tommy1951, createdTime=Wed Apr 18 13:00:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519032, encodeId=0dfd1519032e0, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Wed Apr 18 13:00:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306560, encodeId=27f330656047, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Tue Apr 17 06:53:22 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306441, encodeId=578f3064418b, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Apr 16 23:25:25 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306426, encodeId=d99a30642620, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Mon Apr 16 22:22:46 CST 2018, time=2018-04-16, status=1, ipAttribution=)]
2018-04-18 bugit

#IFN#

21 0
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2018-04-17 kafei

学习学习

63 0
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2018-04-16 1ddf0692m34(暂无匿称)

学习了.长知识

70 0
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2018-04-16 秀红

学习了

77 0

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