Sci Transl Med:复发性A型链球菌扁桃体炎是一种免疫敏感性疾病

2019-02-11 AlexYang MedSci原创

脓毒性咽喉炎在儿童中高度流行,但是为什么仅在某些儿童中发展为复发性扁桃体炎(RT)仍旧不清楚。最近,有研究人员为了进一步认识该经典的儿童疾病,对2个独立的群体-小儿A型链球菌(GAS)RT和非RT扁桃体进行了表型、基因型和功能性研究。研究发现,GAS RT扁桃体具有更小的生发中心,且GAS特异性CD4+生发中心T滤泡辅助细胞(GC-TFH)数量不足。RT儿童表现出了对重要的GAS病毒因子链球菌发热

脓毒性咽喉炎在儿童中高度流行,但是为什么仅在某些儿童中发展为复发性扁桃体炎(RT)仍旧不清楚。最近,有研究人员为了进一步认识该经典的儿童疾病,对2个独立的群体-小儿A型链球菌(GAS)RT和非RT扁桃体进行了表型、基因型和功能性研究。

研究发现,GAS RT扁桃体具有更小的生发中心,且GAS特异性CD4+生发中心T滤泡辅助细胞(GC-TFH)数量不足。RT儿童表现出了对重要的GAS病毒因子链球菌发热性外毒素A(SpeA)抗体响应的减少。研究人员还鉴定了RT的风险和保护性人类白细胞抗原(HLA)II类等位基因。最后,研究人员在RT扁桃体患者中还发现SpeA能够诱导GC-TFH细胞中颗粒酶B的产生,从而杀死B细胞且具有阻碍生发中心响应的能力。

最后,研究人员指出,他们的观察结果表明了RT是一种多因素的疾病,并且导致RT敏感性的贡献因素包括了II类HLA差异、异常的SpeA激活GC-TFH细胞和更低的SpeA抗体滴度。

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    2019-10-27 bsmagic9140
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    2019-02-15 1ddf0692m34(暂无匿称)

    学习了长知识

    0

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