JAHA:三尖瓣环形平面收缩期偏移评估的右心室功能可预测一般人群心血管死亡

2019-05-15 xing.T 网络

通过TAPSE评估的RV收缩功能与一般人群中的CVD相关。在一般人群中,RV收缩功能的评估可提供关于CVD风险新的预后信息。

血管疾病仍然是导致死亡的主要原因。右心室(RV)功能是许多血管疾病结局的强有力预测因子,但其重要性往往被忽视。关于RV收缩功能在一般人群中的预后价值知之甚少。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在确定通过三尖瓣环状平面收缩期偏移(TAPSE)评估的RV收缩功能在预测一般人群的心血管死亡(CVD)的价值。

来自没有心力衰竭或心房颤动的一般人群的总共1039名参与者进行了超声心动图并且测量了TAPSE。该研究主要终点是CVD。

在中位随访12.7年(四分位数间距为12.0-12.9年)期间,69名参与者(6.6%)经历了CVD,而162名参与者(15.6%)经历了非CVD。通过TAPSE评估的RV收缩功能降低是CVD的单变量预测因子(每减少1mm的风险比为1.13; 95%CI为1.07-1.20; P<0.001)。在调整临床和超声心动图参数后,TAPSE仍然是CVD的独立预测因子(每减少1mm的风险比为1.08; 95%CI为1.01-1.15; P=0.017)。此外,在净重新分类分析中,通过TAPSE评估的RV收缩功能降低,当将从系统性冠状动脉风险评估图表或美国心脏协会/美国心脏病学会汇总队列方程修改版本获得的已知心血管危险因素添加到模型时,可显著改善了CVD的风险分类。通过TAPSE评估的RV收缩功能降低未能预测非CVD,表明CVD特异性。

由此可见,通过TAPSE评估的RV收缩功能与一般人群中的CVD相关。在一般人群中,RV收缩功能的评估可提供关于CVD风险新的预后信息。 

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    2019-05-17 zhouqu_8
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