Crit care med:脓毒症使用肾脏替代治疗的效果如何?

2017-12-12 MedSci MedSci原创

目前,脓毒症患者的急性肾脏替代治疗急剧增加,医疗成本大幅增加。然而,各医院使用的差异以及良好的使用效果是否与更好的结果有关尚不得而知。近期,一项发表在杂志Crit care med上的研究进行了回顾性队列分析,对2011年全国18岁以上的脓毒症和急性肾损伤的住院病人进行了抽样检测。此项研究估计了每家医院的脓毒症和急性肾损伤患者使用急性肾脏替代治疗的风险和可靠性调整率。在调整了患者和医院特征后,研究

目前,脓毒症患者的急性肾脏替代治疗急剧增加,医疗成本大幅增加。然而,各医院使用的差异以及良好的使用效果是否与更好的结果有关尚不得而知。

近期,一项发表在杂志Crit care med上的研究进行了回顾性队列分析,对2011年全国18岁以上的脓毒症和急性肾损伤的住院病人进行了抽样检测。

此项研究估计了每家医院的脓毒症和急性肾损伤患者使用急性肾脏替代治疗的风险和可靠性调整率。在调整了患者和医院特征后,研究者们检查了医院特异性肾替代治疗率与住院死亡率和住院费用之间的关系。

最终,此项研究在440家医院确诊了293,899例脓毒症和急性肾损伤住院患者,其中6.4%(n = 18,885)的患者接受了肾脏替代治疗。风险和信度调整后,脓毒症和急性肾损伤患者的住院肾替代治疗中位数为3.6%(四分位间距2.9-4.5%)。然而,肾替代疗法使用率最高的医院的比例为4.8%至13.4%。医院特异性肾替代治疗率与院内死亡率无显着相关性(肾替代治疗率每增加1%的比值比为1.03,95%CI为0.99-1.07;P = 0.10)。随着肾脏替代治疗率的增加,(肾脏替代治疗率每增加1%,绝对成本增加:1,316;95%CI,$ 157- $ 2,475; P = 0.03),医院的费用也显着增加。

在此项全国抽样的医院研究中,使用肾替代疗法在脓毒症中差异很大,没有相关的死亡率差异。改善开始脓毒症治疗的肾替代治疗标准可以降低医疗成本,并且不会增加死亡率。

原始出处:
Valley TS, Nallamothu BK, et al. Hospital Variation in Renal Replacement Therapy for Sepsis in the United States. Crit Care Med. 2017 Dec 4. doi: 10.1097/CCM.0000000000002878.

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    2017-12-13 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

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    2017-12-13 虈亣靌

    不错的.学习了!谢谢分享!

    0

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    2017-12-12 stupidox

    不错,学习了

    0

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