J Gastro: 糖尿病患者肝细胞癌的发生几率分析

2021-01-18 MedSci原创 MedSci原创

在全球范围内,肝癌是第七大最常见的癌症,也是第四大最常见的死因。在2008年,估计约有77%的肝癌病例归因于乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)感染。

      在全球范围内,肝癌是第七大最常见的癌症,也是第四大最常见的死因。在2008年,估计约有77%的肝癌病例归因于乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)感染虽然HCC是病毒导致癌症的典型例子,但它也与生活方式密切相关。越来越多的证据表明,肥胖和糖尿病增加各种癌症的风险,由于过去四十年中饮食习惯的变化,日本各个年龄段的男性和老年女性中超重男性的比例持续增加。在超重和肥胖人口的增加导致的糖尿病患者和脂肪肝数量明显增加。尽管2型糖尿病(T2DM)是肝细胞癌(HCC)发展的已知危险因素。这项研究旨在评估糖尿病患者中HCC的危险因素。

 

 

      该研究包括239例2010年至2015年间被诊断为非病毒性HCC的T2DM患者,在日本81所教学医院进行了≥5年的随访,直到HCC确诊,同时研究人员收集了3277例非HCC T2DM患者作为对照。

 

 

      研究结果显示在HCC诊断时的平均患者年龄约为73岁,其中80%是男性。使用胰岛素的患者比例增加,而体重指数(BMI),患有脂肪肝的患者比例,空腹血糖水平和血红蛋白A1c(HbA1c)水平在5年内显着下降。在队列研究中,有18位患者在平均4.7年的随访期间发展为HCC,年发生率为0.11%。多元逻辑回归分析表明,糖尿病患者发生HCC的概率与男性,高血压,血红蛋白(HbA1c)和白蛋白水平降低,BMI和γ-谷氨酰转肽酶水平升高明显相关。

 

 

      通过本项研究发现:男性,高血压,血红蛋白(HbA1c)和白蛋白水平降低,BMI和γ-谷氨酰转肽酶水平升高都是糖尿病患者发生HCC的危险因素。

 

 

 

原始出处:

Ryosuke Tateishi. et al. Hepatocellular carcinoma development in diabetic patients: a nationwide survey in Japan. J Gastroenterology.2021.

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    2021-06-11 许安
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    2021-08-20 xjy02
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    2021-01-18 misszhang

    谢谢MedSci提供最新的资讯

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