JCEM:新发1型和2型糖尿病患者炎症生物标志物与肾小球滤过率之间的关系

2020-09-04 网络 网络

尽管炎症与糖尿病患者的肾功能有关,但在新诊断的糖尿病中炎症与肾功能可能的关联尚不清楚。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology &

尽管炎症与糖尿病患者的肾功能有关,但在新诊断的糖尿病中炎症与肾功能可能的关联尚不清楚。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在调查新发糖尿病患者炎症和肾脏功能生物标志物之间的横断面和前瞻性关联。

该研究纳入了德国糖尿病研究(GDS)中糖尿病患病时间为1年的1型和2型糖尿病患者。研究人员使用邻近延伸分析技术测量了74个生物标志物的基线血清浓度,并使用多元线性和Logistic回归分析评估了它们与5年内估计的肾小球滤过率(eGFR)和肾功能下降之间的关联。

该横断面分析纳入了165名1型糖尿病患者和291名2型糖尿病患者。与2型糖尿病患者相比,1型糖尿病患者基线eGFR更高(102±5 vs. 90±6 mL/min/1.73m2;p=0.0001)。在对协变量进行全面调整和多项检测后,1型糖尿病患者7种生物标志物与较低的基线eGFR相关,2型糖尿病患者24种生物标志物与较低的基线eGFR相关。在这些生物标记物中,6种生物标记(CD5、CCL23、CST5、IL-10RB、PD-L1和TNFRSF9)与两种糖尿病患者的eGFR呈负相关。前瞻性分析未发现炎症生物标志物与肾功能下降之间的关联。没有发现糖尿病类型和炎症生物标志物之间存在相互作用的证据。

由此可见,几种炎症生物标志物与新发1型和2型糖尿病患者较低的基线eGFR有关,但与糖尿病诊断后最初5年内肾功能丧失无关。

原始出处:

Haifa Maalmi,et al.Biomarkers of inflammation and glomerular filtration rate in individuals with recent-onset type 1 and type 2 diabetes.JCEM.2020.https://doi.org/10.1210/clinem/dgaa622

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    2021-03-31 achengzhao
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href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Sep 06 03:08:06 CST 2020, time=2020-09-06, status=1, ipAttribution=)]
    2021-01-29 14815e22m43暂无昵称

    学习

    0

  5. 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href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Sun Sep 06 03:08:06 CST 2020, time=2020-09-06, status=1, ipAttribution=)]
    2021-07-05 smallant2015
  6. 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  7. 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