J Periodontal Res:苯妥英钠改善牙龈成纤维细胞衰老的过程与自噬通路有关

2020-04-30 网络 网络

人牙龈成纤维组织衰老是牙周病的重要原因。苯妥英钠具有牙龈增生的副作用,并与自噬相关。本研究探讨了苯妥英钠对衰老牙龈成纤维细胞的影响是否与自噬途径有关。

人牙龈成纤维组织衰老是牙周病的重要原因。苯妥英钠具有牙龈增生的副作用,并与自噬相关。本研究探讨了苯妥英钠对衰老牙龈成纤维细胞的影响是否与自噬途径有关。

本实验采用过氧化氢(H2O2)诱导牙龈成纤维细胞系HGF-1衰老模型,同时使用苯妥英钠和3-甲基腺嘌呤(3-MA)处理。采用流式细胞仪检测细胞活性、细胞周期和细胞内钙离子。碱性成纤维细胞生长因子(bFGF)、P16INK4A、P21cip1,bFGF、P16INK4A、P21cip1、LC3II、p62和Beclin的表达变化分别使用反转录聚合酶链反应、western blot和免疫荧光染色法检测。

结果显示,H2O2抑制了衰老的HGF-1增殖,bFGF、P16INK4A、P21cip1的基因和蛋白表达降低,自噬相关蛋白LC3II、p62、Becline降低,细胞周期G0/G1期和细胞内钙离子比例增加。苯妥英钠治疗可改善上述变化,且苯妥英钠的作用可被3-MA阻断。

因此,苯妥英钠可缓解H2O2诱导的牙龈成纤维细胞衰老过程,这种过程与自噬通路的增强有关。

原文出处:

Yi Kang, Phenytoin sodium‐ameliorated gingival fibroblast aging is associated with autophagy, journal of periodontal research, 2020, doi:10.1111/jre.12750

 

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