Stroke:家族性和散发性颅内动脉瘤破裂风险比较

2019-04-25 xing.T 网络

该研究的结果表明,与散发性IA相比,家族性动脉瘤破裂的风险略有增加,尽管研究人员无法证明具有统计学意义。然而,与先前的研究相比,破裂风险似乎没有那么明显地增加。根据该研究的结果,研究人员建议更积极地治疗家族性UIA。

在一项高度选择的家族性动脉瘤研究中,使用来自其他人群的散发患者作为对照,研究人员发现家族性颅内动脉瘤(IA)患者与散发性IA患者相比,其破裂率更高。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在荷兰家族性和散发性IA患者大型独立队列中验证这些发现。

研究人员对1994年至2016年期间筛查IAs的患者队列进行了二次分析,并进行Cox回归分析评估了家族性患者,定义为受动脉瘤性蛛网膜下腔出血和未破裂的IA(UIA)影响的一级亲属≥2,和散发性UIA患者动脉瘤性蛛网膜下腔出血的发生率。

研究人员确定了62例家族性IA患者,91例UIA患者,412例散发性IA患者,542例UIA患者。尽管家族性动脉瘤较小并且通常位于低风险部位而不是散发性IA,但3例家族性患者出现动脉瘤性蛛网膜下腔出血(每100例动脉瘤患者每年出现0.77例破裂[95%CI为0.20-2.09]),而7例散发性出血出现动脉瘤性蛛网膜下腔出血(每100例动脉瘤患者每年出现0.51例破裂[95%CI,0.22-1.01])。与散发性UIA相比,家族性UIA的破裂风险似乎高出3倍(风险比为2.9 [95%CI为0.6-14])。

该研究的结果表明,与散发性IA相比,家族性动脉瘤破裂的风险略有增加,尽管研究人员无法证明具有统计学意义。然而,与先前的研究相比,破裂风险似乎没有那么明显地增加。根据该研究的结果,研究人员建议更积极地治疗家族性UIA。 

原始出处:

Liselore A. Mensing.et al.Comparison of Rupture Risk of Intracranial Aneurysms Between Familial and Sporadic Patients.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023783

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    2020-02-08 zxxiang
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    2019-05-12 用户被禁用

    感谢分享,学习了

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2041714, encodeId=49862041e14d6, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Jul 15 15:38:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078459, encodeId=4d2420e845928, content=<a href='/topic/show?id=1842100886df' target=_blank style='color:#2F92EE;'>#风险比#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100886, encryptionId=1842100886df, topicName=风险比)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Mon Sep 09 01:38:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043021, encodeId=7e1b2043021f5, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Sat Feb 08 05:38:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366118, encodeId=ac6f3661180f, content=感谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/04/23/fa6ad39852b3fd26b8f7093d53c322a1.jpg, createdBy=807b5083691, createdName=用户被禁用, createdTime=Sun May 12 17:10:48 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053336, encodeId=09c120533361c, content=<a href='/topic/show?id=a4c91003847b' target=_blank style='color:#2F92EE;'>#颅内动脉瘤破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100384, encryptionId=a4c91003847b, topicName=颅内动脉瘤破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Tue Sep 03 22:38:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629547, encodeId=da10162954e21, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Apr 27 06:38:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365327, encodeId=307a36532e55, content=学习了,长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Apr 26 23:19:07 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365271, encodeId=8e0b3652e15a, content=已学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59d05085427, createdName=145c08f8m03暂无昵称, createdTime=Fri Apr 26 01:23:51 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365244, encodeId=ea8e365244b1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Apr 25 17:14:33 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2041714, encodeId=49862041e14d6, content=<a href='/topic/show?id=9ce4e34862a' target=_blank style='color:#2F92EE;'>#破裂风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73486, encryptionId=9ce4e34862a, topicName=破裂风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Mon Jul 15 15:38:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2078459, encodeId=4d2420e845928, content=<a href='/topic/show?id=1842100886df' target=_blank style='color:#2F92EE;'>#风险比#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100886, encryptionId=1842100886df, topicName=风险比)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Mon Sep 09 01:38:00 CST 2019, time=2019-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043021, encodeId=7e1b2043021f5, content=<a href='/topic/show?id=88535e63128' target=_blank style='color:#2F92EE;'>#散发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57631, encryptionId=88535e63128, topicName=散发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f5a410, createdName=zxxiang, createdTime=Sat Feb 08 05:38:00 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366118, encodeId=ac6f3661180f, content=感谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/04/23/fa6ad39852b3fd26b8f7093d53c322a1.jpg, createdBy=807b5083691, createdName=用户被禁用, createdTime=Sun May 12 17:10:48 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053336, encodeId=09c120533361c, content=<a href='/topic/show?id=a4c91003847b' target=_blank style='color:#2F92EE;'>#颅内动脉瘤破裂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100384, encryptionId=a4c91003847b, topicName=颅内动脉瘤破裂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=640c454, createdName=qblt, createdTime=Tue Sep 03 22:38:00 CST 2019, time=2019-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629547, encodeId=da10162954e21, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Apr 27 06:38:00 CST 2019, time=2019-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365327, encodeId=307a36532e55, content=学习了,长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Apr 26 23:19:07 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365271, encodeId=8e0b3652e15a, content=已学习,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59d05085427, createdName=145c08f8m03暂无昵称, createdTime=Fri Apr 26 01:23:51 CST 2019, time=2019-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365244, encodeId=ea8e365244b1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Apr 25 17:14:33 CST 2019, time=2019-04-25, status=1, ipAttribution=)]
    2019-04-26 1ddf0692m34(暂无匿称)

    学习了,长知识

    0

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    2019-04-26 145c08f8m03暂无昵称

    已学习,谢谢分享

    0

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    2019-04-25 一个字-牛

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